Thiamine-triphosphatase

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In enzymology, a thiamine-triphosphatase (EC 3.6.1.28) is an enzyme that catalyzes the chemical reaction

thiamine triphosphate + H₂O thiamine diphosphate + phosphate

Thus, the two substrates of this enzyme are thiamine triphosphate and H₂O, whereas its two products are thiamine diphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is thiamine-triphosphate phosphohydrolase. This enzyme participates in thiamine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JMU.

[edit] References

• IUBMB entry for 3.6.1.28
• BRENDA references for 3.6.1.28 (Recommended.)
• PubMed references for 3.6.1.28
• PubMed Central references for 3.6.1.28
• Google Scholar references for 3.6.1.28
• Hashitani Y, Cooper JR (1972). "The partial purification of thiamine triphosphatase from rat brain". J. Biol. Chem. 247: 2117–9. PMID 4335862. 

[edit] External links

The CAS registry number for this enzyme class is 9068-47-7.

• IUBMB entry for 3.6.1.28

• KEGG entry for 3.6.1.28

• BRENDA entry for 3.6.1.28

• NiceZyme view of 3.6.1.28

• EC2PDB: PDB structures for 3.6.1.28

• PRIAM entry for 3.6.1.28

• PUMA2 entry for 3.6.1.28

• IntEnz: Integrated Enzyme entry for 3.6.1.28

• MetaCyc entry for 3.6.1.28

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050333: thiamin-triphosphatase

• AMIGO entry for GO code 0050333: thiamin-triphosphatase