Thetin-homocysteine S-methyltransferase

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In enzymology, a thetin-homocysteine S-methyltransferase (EC 2.1.1.3) is an enzyme that catalyzes the chemical reaction

dimethylsulfonioacetate + L-homocysteine $\rightleftharpoons$ S-methylthioglycolate + L-methionine

Thus, the two substrates of this enzyme are dimethylsulfonioacetic acid and L-homocysteine, whereas its two products are S-methylthioglycolic acid and L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is dimethylsulfonioacetic acid:L-homocysteine S-methyltransferase. Other names in common use include dimethylthetin-homocysteine methyltransferase, and thetin-homocysteine methylpherase.

[edit] References

IUBMB entry for 2.1.1.3
BRENDA references for 2.1.1.3 (Recommended.)
PubMed references for 2.1.1.3
PubMed Central references for 2.1.1.3
Google Scholar references for 2.1.1.3
KLEE WA, RICHARDS HH, CANTONI GL (1961). "The synthesis of methionine by enzymic transmethylation. VII Existence of two separate homocysteine methylpherases on mammalian liver". Biochim. Biophys. Acta. 54: 157–64. doi:10.1016/0006-3002(61)90948-9. PMID 14456704.
MAW GA (1956). "Thetin-homocysteine transmethylase; a preliminary manometric study of the enzyme from rat liver". Biochem. J. 63: 116–24. PMID 13315256.
MAW GA (1958). "Thetin-homocysteine transmethylase; some further characteristics of the enzyme from rat liver". Biochem. J. 70: 168–73. PMID 13584318.