TFB1M

From Wikipedia, the free encyclopedia

Transcription factor B1, mitochondrial

Identifiers

TFB1M; CGI-75; CGI75; mtTFB

External IDs

OMIM: 607033 MGI: 2146851 HomoloGene: 9343

Gene ontology
Molecular Function:	• rRNA (adenine-N6,N6-)-dimethyltransferase activity • DNA binding • methyltransferase activity • rRNA methyltransferase activity • transferase activity
Cellular Component:	• mitochondrion
Biological Process:	• rRNA modification • transcription • regulation of transcription, DNA-dependent • rRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016020 (mRNA)
NP_057104 (protein)

NM_146074 (mRNA)
NP_666186 (protein)

Location

Chr 6: 155.62 - 155.68 Mb

Chr 17: 3.48 - 3.51 Mb

Pubmed search

[1]

[2]

Transcription factor B1, mitochondrial, also known as TFB1M, is a human gene.^[1]

The transcription of genes from mitochondrial DNA requires a mitochondrial RNA polymerase (see POLRMT, MIM 601778) and a DNA-binding transcription factor (see TFAM, MIM 600438). Transcription factor B1 (TFB1M) is a part of this transcription complex.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TFB1M transcription factor B1, mitochondrial.

[edit] Further reading

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703-13. PMID 10810093.
McCulloch V, Seidel-Rogol BL, Shadel GS (2002). "A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine.". Mol. Cell. Biol. 22 (4): 1116-25. PMID 11809803.
Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.". Nat. Genet. 31 (3): 289-94. doi:10.1038/ng909. PMID 12068295.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Seidel-Rogol BL, McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop.". Nat. Genet. 33 (1): 23-4. doi:10.1038/ng1064. PMID 12496758.
Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.". Mamm. Genome 14 (1): 1-6. doi:10.1007/s00335-002-2218-z. PMID 12532263.
McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity.". Mol. Cell. Biol. 23 (16): 5816-24. PMID 12897151.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Bykhovskaya Y, Mengesha E, Wang D, et al. (2004). "Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation.". Mol. Genet. Metab. 82 (1): 27-32. doi:10.1016/j.ymgme.2004.01.020. PMID 15110318.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators.". Mol. Cell. Biol. 25 (4): 1354-66. doi:10.1128/MCB.25.4.1354-1366.2005. PMID 15684387.
Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.". Nucleic Acids Res. 35 (12): 4042-54. doi:10.1093/nar/gkm424. PMID 17557812.