Terephthalate 1,2-cis-dihydrodiol dehydrogenase

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In enzymology, a terephthalate 1,2-cis-dihydrodiol dehydrogenase (EC 1.3.1.61) is an enzyme that catalyzes the chemical reaction

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD⁺ 3,4-dihydroxybenzoate + CO₂ + NADH

Thus, the two substrates of this enzyme are cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate and NAD⁺, whereas its 3 products are 3,4-dihydroxybenzoate, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in 2,4-dichlorobenzoate degradation.

[edit] References

• IUBMB entry for 1.3.1.61
• BRENDA references for 1.3.1.61 (Recommended.)
• PubMed references for 1.3.1.61
• PubMed Central references for 1.3.1.61
• Google Scholar references for 1.3.1.61
• Wang YZ, Zhou Y, Zylstra GJ (1995). "Molecular analysis of isophthalate and terephthalate degradation by Comamonas testosteroni YZW-D". Environ. Health. Perspect. 103 Suppl 5: 9–12. PMID 8565920. 

[edit] External links

• IUBMB entry for 1.3.1.61

• KEGG entry for 1.3.1.61

• BRENDA entry for 1.3.1.61

• NiceZyme view of 1.3.1.61

• EC2PDB: PDB structures for 1.3.1.61

• PRIAM entry for 1.3.1.61

• PUMA2 entry for 1.3.1.61

• IntEnz: Integrated Enzyme entry for 1.3.1.61

• MetaCyc entry for 1.3.1.61

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018514: terephthalate 1,2-cis-dihydrodiol dehydrogenase

• AMIGO entry for GO code 0018514: terephthalate 1,2-cis-dihydrodiol dehydrogenase