Teratocarcinoma-derived growth factor 1

From Wikipedia, the free encyclopedia

Identifiers

TDGF1; CR; CRGF; CRIPTO; Cripto-1

External IDs

OMIM: 187395 MGI: 98658 HomoloGene: 2416

Gene ontology
Molecular Function:	• growth factor activity
Cellular Component:	• cell surface • extrinsic to plasma membrane
Biological Process:	• activation of MAPK activity • morphogenesis of a branching structure • epidermal growth factor receptor signaling pathway • heart development • positive regulation of cell proliferation • determination of anterior/posterior axis, embryo • embryonic development • regulation of signal transduction • peptidyl-serine phosphorylation • cell differentiation • positive regulation of cell migration • mammary gland development • negative regulation of apoptosis • positive regulation of peptidyl-tyrosine phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003212 (mRNA)
NP_003203 (protein)

NM_011562 (mRNA)
NP_035692 (protein)

Location

Chr 3: 46.59 - 46.6 Mb

n/a

Pubmed search

[1]

[2]

Teratocarcinoma-derived growth factor 1, also known as TDGF1, is a human gene.^[1]

[edit] References

^ Entrez Gene: TDGF1 teratocarcinoma-derived growth factor 1.

[edit] Further reading

Salomon DS, Bianco C, De Santis M (1999). "Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia.". Bioessays 21 (1): 61–70. doi:10.1002/(SICI)1521-1878(199901)21:1<61::AID-BIES8>3.0.CO;2-H. PMID 10070255.
Adamson ED, Minchiotti G, Salomon DS (2002). "Cripto: a tumor growth factor and more.". J. Cell. Physiol. 190 (3): 267–78. doi:10.1002/jcp.10072. PMID 11857442.
Dono R, Montuori N, Rocchi M, et al. (1991). "Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence.". Am. J. Hum. Genet. 49 (3): 555–65. PMID 1882841.
Ciccodicola A, Dono R, Obici S, et al. (1989). "Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells.". EMBO J. 8 (7): 1987–91. PMID 2792079.
Saccone S, Rapisarda A, Motta S, et al. (1995). "Regional localization of the human EGF-like growth factor CRIPTO gene (TDGF-1) to chromosome 3p21.". Hum. Genet. 95 (2): 229–30. PMID 7860072.
Brandt R, Normanno N, Gullick WJ, et al. (1994). "Identification and biological characterization of an epidermal growth factor-related protein: cripto-1.". J. Biol. Chem. 269 (25): 17320–8. PMID 8006041.
Friess H, Yamanaka Y, Büchler M, et al. (1994). "Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis.". Int. J. Cancer 56 (5): 668–74. PMID 8314343.
Panico L, D'Antonio A, Salvatore G, et al. (1996). "Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues.". Int. J. Cancer 65 (1): 51–6. doi:10.1002/(SICI)1097-0215(19960103)65:1<51::AID-IJC9>3.0.CO;2-0. PMID 8543395.
Kannan S, De Santis M, Lohmeyer M, et al. (1997). "Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.". J. Biol. Chem. 272 (6): 3330–5. PMID 9013573.
Xu C, Liguori G, Adamson ED, Persico MG (1998). "Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1.". Dev. Biol. 196 (2): 237–47. doi:10.1006/dbio.1998.8862. PMID 9576836.
Xu C, Liguori G, Persico MG, Adamson ED (1999). "Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes.". Development 126 (3): 483–94. PMID 9876177.
Scognamiglio B, Baldassarre G, Cassano C, et al. (1999). "Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1.". Cytogenet. Cell Genet. 84 (3-4): 220–4. PMID 10393436.
Ebert AD, Wechselberger C, Frank S, et al. (1999). "Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells.". Cancer Res. 59 (18): 4502–5. PMID 10493495.
Reissmann E, Jörnvall H, Blokzijl A, et al. (2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.". Genes Dev. 15 (15): 2010–22. doi:10.1101/gad.201801. PMID 11485994.
Bianco C, Adkins HB, Wechselberger C, et al. (2002). "Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.". Mol. Cell. Biol. 22 (8): 2586–97. PMID 11909953.
Yan YT, Liu JJ, Luo Y, et al. (2002). "Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.". Mol. Cell. Biol. 22 (13): 4439–49. PMID 12052855.
de la Cruz JM, Bamford RN, Burdine RD, et al. (2002). "A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects.". Hum. Genet. 110 (5): 422–8. doi:10.1007/s00439-002-0709-3. PMID 12073012.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.