TERF2IP

From Wikipedia, the free encyclopedia

Telomeric repeat binding factor 2, interacting protein

PDB rendering based on 1fex.

Available structures: 1fex

Identifiers

Symbol(s)

TERF2IP; RAP1; DRIP5

External IDs

OMIM: 605061 MGI: 1929871 HomoloGene: 10357

Gene ontology
Molecular Function:	• DNA binding • protein binding • single-stranded telomeric DNA binding
Cellular Component:	• nuclear chromosome • chromosome, telomeric region • nucleus
Biological Process:	• telomere maintenance via telomerase • regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018975 (mRNA)
NP_061848 (protein)

NM_020584 (mRNA)
NP_065609 (protein)

Location

Chr 16: 74.24 - 74.25 Mb

Chr 8: 114.9 - 114.91 Mb

Pubmed search

[1]

[2]

Telomeric repeat binding factor 2, interacting protein, also known as TERF2IP, is a human gene.^[1]

[edit] References

^ Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein.

[edit] Further reading

Li B, Oestreich S, de Lange T (2000). "Identification of human Rap1: implications for telomere evolution.". Cell 101 (5): 471–83. PMID 10850490.
Zhu XD, Küster B, Mann M, et al. (2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.". Nat. Genet. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888.
Hanaoka S, Nagadoi A, Yoshimura S, et al. (2001). "NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains.". J. Mol. Biol. 312 (1): 167–75. doi:10.1006/jmbi.2001.4924. PMID 11545594.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Loayza D, De Lange T (2003). "POT1 as a terminal transducer of TRF1 telomere length control.". Nature 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.
Li B, de Lange T (2004). "Rap1 affects the length and heterogeneity of human telomeres.". Mol. Biol. Cell 14 (12): 5060–8. doi:10.1091/mbc.E03-06-0403. PMID 14565979.
Zhu XD, Niedernhofer L, Kuster B, et al. (2004). "ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.". Mol. Cell 12 (6): 1489–98. PMID 14690602.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
O'Connor MS, Safari A, Liu D, et al. (2004). "The human Rap1 protein complex and modulation of telomere length.". J. Biol. Chem. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. PMID 15100233.
Liu D, Safari A, O'Connor MS, et al. (2004). "PTOP interacts with POT1 and regulates its localization to telomeres.". Nat. Cell Biol. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Ye JZ, Donigian JR, van Overbeek M, et al. (2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.". J. Biol. Chem. 279 (45): 47264–71. doi:10.1074/jbc.M409047200. PMID 15316005.
Liu D, O'Connor MS, Qin J, Songyang Z (2005). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.". J. Biol. Chem. 279 (49): 51338–42. doi:10.1074/jbc.M409293200. PMID 15383534.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMID 15498874.
Antoine K, Ferbus D, Kolahgar G, et al. (2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1.". J. Cell. Biochem. 95 (4): 763–8. doi:10.1002/jcb.20487. PMID 15838871.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Wu Y, Zacal NJ, Rainbow AJ, Zhu XD (2007). "XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening.". DNA Repair (Amst.) 6 (2): 157–66. doi:10.1016/j.dnarep.2006.09.005. PMID 17055345.
Bae NS, Baumann P (2007). "A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends.". Mol. Cell 26 (3): 323–34. doi:10.1016/j.molcel.2007.03.023. PMID 17499040.