TEP1

From Wikipedia, the free encyclopedia

Telomerase-associated protein 1

Identifiers

TEP1; TLP1; TP1; TROVE1; VAULT2; p240

External IDs

OMIM: 601686 MGI: 109573 HomoloGene: 5157

Gene ontology
Molecular Function:	• nucleotide binding • telomerase activity • RNA binding • ATP binding
Cellular Component:	• chromosome, telomeric region • soluble fraction • nucleus • chromosome • telomerase holoenzyme complex • cytoplasm • nuclear matrix
Biological Process:	• telomere maintenance via recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007110 (mRNA)
NP_009041 (protein)

XM_985651 (mRNA)
XP_990745 (protein)

Location

Chr 14: 19.91 - 19.95 Mb

Chr 14: 49.75 - 49.79 Mb

Pubmed search

[1]

[2]

Telomerase-associated protein 1, also known as TEP1, is a human gene.^[1]

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.^[1]

[edit] References

^ ^a ^b Entrez Gene: TEP1 telomerase-associated protein 1.

[edit] Further reading

Joly EC, Tremblay E, Tanguay RM, et al. (1995). "TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix.". J. Cell. Sci. 107 ( Pt 10): 2851–9. PMID 7876352.
Harrington L, McPhail T, Mar V, et al. (1997). "A mammalian telomerase-associated protein.". Science 275 (5302): 973–7. PMID 9020079.
Harrington L, Zhou W, McPhail T, et al. (1998). "Human telomerase contains evolutionarily conserved catalytic and structural subunits.". Genes Dev. 11 (23): 3109–15. PMID 9389643.
Saito T, Matsuda Y, Suzuki T, et al. (1998). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases.". Genomics 46 (1): 46–50. PMID 9403057.
Li H, Zhao L, Yang Z, et al. (1999). "Telomerase is controlled by protein kinase Calpha in human breast cancer cells.". J. Biol. Chem. 273 (50): 33436–42. PMID 9837921.
Kickhoefer VA, Stephen AG, Harrington L, et al. (2000). "Vaults and telomerase share a common subunit, TEP1.". J. Biol. Chem. 274 (46): 32712–7. PMID 10551828.
Li H, Cao Y, Berndt MC, et al. (2000). "Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro.". Oncogene 18 (48): 6785–94. doi:10.1038/sj.onc.1203061. PMID 10597287.
Koyanagi Y, Kobayashi D, Yajima T, et al. (2000). "Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells.". Anticancer Res. 20 (2A): 773–8. PMID 10810353.
Beattie TL, Zhou W, Robinson MO, Harrington L (2000). "Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding.". Mol. Biol. Cell 11 (10): 3329–40. PMID 11029039.
Zhang RG, Zhang RP, Wang XW, Xie H (2004). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells.". Cell Res. 12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID 11942411.
Chang JT, Chen YL, Yang HT, et al. (2002). "Differential regulation of telomerase activity by six telomerase subunits.". Eur. J. Biochem. 269 (14): 3442–50. PMID 12135483.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhou JH, Zhang HM, Chen Q, et al. (2003). "Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma.". World J. Gastroenterol. 9 (8): 1808–14. PMID 12918126.
Li C, Wu MY, Liang YR, Wu XY (2003). "Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma.". World J. Gastroenterol. 9 (11): 2395–9. PMID 14606063.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.