TENC1

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Tensin like C1 domain containing phosphatase (tensin 2)
PDB rendering based on 2dkq.
Available structures: 2dkq
Identifiers
Symbol(s) TENC1; C1-TEN; C1TEN; DKFZp686D13244; FLJ16320; KIAA1075; TNS2
External IDs OMIM: 607717 MGI: 2387586 HomoloGene: 37077
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23371 209039
Ensembl ENSG00000111077 ENSMUSG00000037003
Refseq NM_015319 (mRNA)
NP_056134 (protein)		 NM_153533 (mRNA)
NP_705761 (protein)
Location Chr 12: 51.73 - 51.74 Mb Chr 15: 101.93 - 101.94 Mb
Pubmed search [1] [2]

Tensin like C1 domain containing phosphatase (tensin 2), also known as TENC1, is a human gene.[1]

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2).

[edit] Further reading

  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197-205. PMID 10470851. 
  • Chen H, Duncan IC, Bozorgchami H, Lo SH (2002). "Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 733-8. doi:10.1073/pnas.022518699. PMID 11792844. 
  • Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.". Biochem. Biophys. Res. Commun. 299 (5): 793-800. PMID 12470648. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Calderwood DA, Fujioka Y, de Pereda JM, et al. (2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2272-7. doi:10.1073/pnas.262791999. PMID 12606711. 
  • Hu Y, Fang X, Dunham SM, et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.". J. Biol. Chem. 279 (28): 29325-35. doi:10.1074/jbc.M311144200. PMID 15117958. 
  • Hafizi S, Ibraimi F, Dahlbäck B (2006). "C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration.". FASEB J. 19 (8): 971-3. doi:10.1096/fj.04-2532fje. PMID 15817639. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Yam JW, Ko FC, Chan CY, et al. (2006). "Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma.". Hepatology 44 (4): 881-90. doi:10.1002/hep.21339. PMID 17006924. 
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