Talk:Telomerase

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Contents

[edit] Update

The structure of human telomerase seems to have been deciphered:

Protein Composition of Catalytically Active Human Telomerase from Immortal Cells (Science Magazine)

Telomerase is a ribonucleoprotein enzyme complex that adds 5'-TTAGGG-3' repeats onto the ends of human chromosomes, providing a telomere maintenance mechanism for 90% of human cancers. We have purified human telomerase 108-fold, with the final elution dependent on the enzyme's ability to catalyze nucleotide addition onto a DNA oligonucleotide of telomeric sequence, thereby providing specificity for catalytically active telomerase. Mass spectrometric sequencing of the protein components and molecular size determination indicated an enzyme composition of two molecules each of telomerase reverse transcriptase, telomerase RNA, and dyskerin.

I think I'll update once there's more published confirmations of the findings. Recurring dreams 12:49, 30 March 2007 (UTC)

Ashermadan:

[edit] Question

Have there been any changes to this model, or is it still widly used by the scientific community?

<next person>:

<Type your answers or questions here in this format>

[edit] Regarding the link to the SmartPublications article

The link leads to a site only looking like an authentic SP site.
Can we get a more official link on this? CharonX 00:06, 8 February 2006 (UTC)

[edit] References Needs the Pubmed Link

Personally, I think all medical topics in Wikipedia should have some kind of link to the National Library of Medicine site, since these very esoteric topics cannot be treated in their full detail. Pubmed.com will fill in the details that Wikipedia cannot provide.

The interesting thing is that just about all of the references have PMID numbers. PMID=Pubmed ID It is not redundant to make mention of the place from whence this comes.

The thing is, virtually every reader who would be likely to be able to make use of the results of a PubMed query will almost certainly know about PubMed already. Remember that for the bulk of results (particularly recent results on a topic like telomerase),
  • The material will be at a high level—technical reviews and articles that require a college-level background in science;
  • Access to much recent material will require a journal subscription (again, typically held by a university library).
The moderately curious will also very rapidly discover what all those PMID tags in the references section point to, and will have some clue of what they're about to get into. Note that an unqualified search for the word 'telomerase' in PubMed draws a shade more than six thousand hits, many of which are highly technical and likely to be of no use to a neophyte.
A minor nitpick, the URL for PubMed is properly http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed. Links to www.pubmed.com get bounced to the proper address. TenOfAllTrades(talk) 13:43, 23 March 2006 (UTC)

[edit] gentic?

What is "gentic anticipation"? Should that be genetic? --darklilac 15:57, 16 August 2006 (UTC)

[edit] Australian scientists discover 2 proteins that can possibly work against Telomerase production in cancer cells

  • [1], intresting read, someone should add this to the article with background knowledge in this field. —The preceding unsigned comment was added by 74.113.107.4 (talk) 23:04, 30 March 2007 (UTC).
  • [2] recent news about the researching into the composition of this enzyme.

[edit] Telomorase activator now on the market under license from Geron

"NEW YORK, April 9, 2007 /PRNewswire via COMTEX/ -- Telomerase Activation Sciences, Inc. (TA Sciences) announced on March 12 its license with Geron to develop and market non-therapeutic products using Geron's small molecule telomerase activators. Now TA Sciences announces the opening of the TA Sciences Center in Manhattan where customers can purchase TA Sciences' first product, a nutraceutical containing the telomerase activating agent "TA-65. "TA Sciences welcomes our first customers and the launch of the world's first telomerase activator product," said Noel Thomas Patton, founder of TA Sciences. "A natural consequence of aging is the shortening of telomeres (caps of DNA located at the ends of all chromosomes), which ultimately results in loss of cell function. TA-65 offers the potential of reducing or reversing telomere shortening and battles tissue and organ degeneration by rejuvenating aging cells." [3] —The preceding unsigned comment was added by Noisy Hand (talk • contribs) 16:55, 11 April 2007 (UTC).

[edit] Telomerase and Stem Cells

I've heard that adult stem cells lack the telomerase of embryonic stem cells, and that because of this difference, adult stem cells are more likely to create stable tissues in therapy than embryonic. Is there any validity to that? —Preceding unsigned comment added by 205.175.225.22 (talk) 15:44, August 27, 2007 (UTC)

[edit] Blackburn's 70 genes?

There is a "Blackburn et al" thrown in the last section of the article referring to this "70 genes" thing but the actual citation is not there and a quick PubMed search has not turned anything up. If someone doesn't add the citation within a few days I will remove the reference in the text. AstarothCY 10:33, 31 October 2007 (UTC)