TEAD4

From Wikipedia, the free encyclopedia

TEA domain family member 4

PDB rendering based on 2hzd.

Available structures: 2hzd

Identifiers

Symbol(s)

TEAD4; EFTR-2; MGC9014; RTEF-1; RTEF1; TCF13L1; TEF-3; TEFR-1; hRTEF-1B

External IDs

OMIM: 601714 MGI: 106907 HomoloGene: 74463

Gene ontology
Molecular Function:	• transcription factor activity • RNA polymerase II transcription factor activity • transcription activator activity
Cellular Component:	• nucleus • transcription factor complex
Biological Process:	• skeletal development • transcription • regulation of transcription, DNA-dependent • muscle development • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003213 (mRNA)
NP_003204 (protein)

NM_001080979 (mRNA)
NP_001074448 (protein)

Location

Chr 12: 2.94 - 3.02 Mb

Chr 6: 128.19 - 128.27 Mb

Pubmed search

[1]

[2]

TEA domain family member 4, also known as TEAD4, is a human gene.^[1]

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: TEAD4 TEA domain family member 4.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Hsu DK, Guo Y, Alberts GF, et al. (1996). "Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation.". J. Biol. Chem. 271 (23): 13786-95. PMID 8662936.
Jacquemin P, Hwang JJ, Martial JA, et al. (1996). "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.". J. Biol. Chem. 271 (36): 21775-85. PMID 8702974.
Stewart AF, Richard CW, Suzow J, et al. (1997). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family.". Genomics 37 (1): 68-76. PMID 8921372.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Jacquemin P, Depetris D, Mattei MG, et al. (1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis.". Genomics 55 (1): 127-9. doi:10.1006/geno.1998.5628. PMID 9889009.
Vaudin P, Delanoue R, Davidson I, et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.". Development 126 (21): 4807-16. PMID 10518497.
Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.". Genes Dev. 15 (10): 1229-41. doi:10.1101/gad.888601. PMID 11358867.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chen HH, Baty CJ, Maeda T, et al. (2005). "Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation.". Circulation 110 (19): 2980-7. doi:10.1161/01.CIR.0000146902.84099.26. PMID 15520314.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Appukuttan B, McFarland TJ, Davies MH, et al. (2007). "Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina.". Invest. Ophthalmol. Vis. Sci. 48 (8): 3775-82. doi:10.1167/iovs.06-1172. PMID 17652751.