TCF12

From Wikipedia, the free encyclopedia

Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)

Identifiers

TCF12; HEB; HTF4; HsT17266

External IDs

OMIM: 600480 MGI: 101877 HomoloGene: 40774

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity • transcription regulator activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• regulation of transcription from RNA polymerase II promoter • immune response • multicellular organismal development • muscle development • regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003205 (mRNA)
NP_003196 (protein)

NM_011544 (mRNA)
NP_035674 (protein)

Location

Chr 15: 55 - 55.37 Mb

Chr 9: 71.64 - 71.91 Mb

Pubmed search

[1]

[2]

Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4), also known as TCF12, is a human gene.^[1]

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: TCF12 transcription factor 12 (HTF4, helix-loop-helix transcription factors 4).

[edit] Further reading

Bain G, Murre C (1998). "The role of E-proteins in B- and T-lymphocyte development.". Semin. Immunol. 10 (2): 143-53. doi:10.1006/smim.1998.0116. PMID 9618760.
Hu JS, Olson EN, Kingston RE (1992). "HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.". Mol. Cell. Biol. 12 (3): 1031-42. PMID 1312219.
Zhang Y, Bina M (1992). "The nucleotide sequence of the human transcription factor HTF4a cDNA.". DNA Seq. 2 (6): 397-403. PMID 1446075.
Zhang Y, Doyle K, Bina M (1992). "Interactions of HTF4 with E-box motifs in the long terminal repeat of human immunodeficiency virus type 1.". J. Virol. 66 (9): 5631-4. PMID 1501295.
Sommer L, Hagenbüchle O, Wellauer PK, Strubin M (1992). "Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence.". Cell 67 (5): 987-94. PMID 1720355.
Zhang Y, Babin J, Feldhaus AL, et al. (1991). "HTF4: a new human helix-loop-helix protein.". Nucleic Acids Res. 19 (16): 4555. PMID 1886779.
Zhang Y, Flejter WL, Barcroft CL, et al. (1995). "Localization of the human HTF4 transcription factors 4 gene (TCF12) to chromosome 15q21.". Cytogenet. Cell Genet. 68 (3-4): 235-8. PMID 7842744.
Doyle K, Zhang Y, Baer R, Bina M (1994). "Distinguishable patterns of protein-DNA interactions involving complexes of basic helix-loop-helix proteins.". J. Biol. Chem. 269 (16): 12099-105. PMID 8163514.
Langlands K, Yin X, Anand G, Prochownik EV (1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors.". J. Biol. Chem. 272 (32): 19785-93. PMID 9242638.
Goldfarb AN, Lewandowska K, Pennell CA (1998). "Identification of a highly conserved module in E proteins required for in vivo helix-loop-helix dimerization.". J. Biol. Chem. 273 (5): 2866-73. PMID 9446597.
Massari ME, Rivera RR, Voland JR, et al. (1998). "Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes.". Mol. Cell. Biol. 18 (6): 3130-9. PMID 9584154.
Adell T, Gómez-Cuadrado A, Skoudy A, et al. (2000). "Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells.". Cell Growth Differ. 11 (3): 137-47. PMID 10768861.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Mandolesi G, Gargano S, Pennuto M, et al. (2002). "NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction.". FEBS Lett. 510 (1-2): 50-6. PMID 11755530.
Knöfler M, Meinhardt G, Bauer S, et al. (2002). "Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains.". Biochem. J. 361 (Pt 3): 641-51. PMID 11802795.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tremblay M, Herblot S, Lecuyer E, Hoang T (2003). "Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.". J. Biol. Chem. 278 (15): 12680-7. doi:10.1074/jbc.M209870200. PMID 12566462.