TCEB3

From Wikipedia, the free encyclopedia

Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)

Identifiers

TCEB3; SIII; TCEB3A

External IDs

OMIM: 600786 MGI: 1351315 HomoloGene: 37746

Gene ontology
Molecular Function:	• transcription elongation regulator activity • protein binding
Cellular Component:	• nucleus • integral to membrane
Biological Process:	• regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003198 (mRNA)
NP_003189 (protein)

NM_013736 (mRNA)
NP_038764 (protein)

Location

Chr 1: 23.94 - 23.96 Mb

Chr 4: 135.28 - 135.29 Mb

Pubmed search

[1]

[2]

Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A), also known as TCEB3, is a human gene.^[1]

This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.^[1]

[edit] References

^ ^a ^b Entrez Gene: TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A).

[edit] Further reading

Shilatifard A (1998). "Factors regulating the transcriptional elongation activity of RNA polymerase II.". FASEB J. 12 (14): 1437–46. PMID 9806752.
Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.
Aso T, Lane WS, Conaway JW, Conaway RC (1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.". Science 269 (5229): 1439–43. PMID 7660129.
Aso T, Mokady N, Haque D, et al. (1996). "Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1.". Genomics 30 (2): 393–4. PMID 8586449.
Aso T, Haque D, Fukudome K, et al. (1996). "A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin.". Gene 168 (2): 277–8. PMID 8654961.
Pan G, Aso T, Greenblatt J (1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators.". J. Biol. Chem. 272 (39): 24563–71. PMID 9305922.
Ohh M, Takagi Y, Aso T, et al. (2000). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.". J. Clin. Invest. 104 (11): 1583–91. PMID 10587522.
Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
Shaheduzzaman S, Krishnan V, Petrovic A, et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles.". J. Biomed. Sci. 9 (1): 82–96. PMID 11810028.
Yamazaki K, Guo L, Sugahara K, et al. (2002). "Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3.". J. Biol. Chem. 277 (29): 26444–51. doi:10.1074/jbc.M202859200. PMID 11994304.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tamura K, Miyata K, Sugahara K, et al. (2003). "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.". Biochem. Biophys. Res. Commun. 309 (1): 189–95. PMID 12943681.
Stoletov KV, Terman BI (2004). "Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation.". Biochem. Biophys. Res. Commun. 320 (1): 70–5. doi:10.1016/j.bbrc.2004.05.134. PMID 15207703.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain.". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMID 16498413.