TCEB2

From Wikipedia, the free encyclopedia

Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

PDB rendering based on 1lm8.

Available structures: 1lm8, 1lqb, 1vcb, 2c9w, 2fnj, 2izv

Identifiers

Symbol(s)

TCEB2; SIII

External IDs

OMIM: 600787 MGI: 1914923 HomoloGene: 38275

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • RNA elongation from RNA polymerase II promoter • protein complex assembly • protein modification process • ubiquitin cycle

Orthologs

Human

Mouse

Refseq

NM_007108 (mRNA)
NP_009039 (protein)

XM_986312 (mRNA)
XP_991406 (protein)

Location

Chr 16: 2.76 - 2.77 Mb

Chr 17: 23.55 - 23.56 Mb

Pubmed search

[1]

[2]

Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B), also known as TCEB2, is a human gene.

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[1]

[edit] References

^ Entrez Gene: TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B).

[edit] Further reading

Garrett KP, Aso T, Bradsher JN, et al. (1995). "Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog.". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7172–6. PMID 7638163.
Duan DR, Pause A, Burgess WH, et al. (1995). "Inhibition of transcription elongation by the VHL tumor suppressor protein.". Science 269 (5229): 1402–6. PMID 7660122.
Aso T, Lane WS, Conaway JW, Conaway RC (1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.". Science 269 (5229): 1439–43. PMID 7660129.
Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG (1995). "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C.". Science 269 (5229): 1444–6. PMID 7660130.
Bradsher JN, Jackson KW, Conaway RC, Conaway JW (1994). "RNA polymerase II transcription factor SIII. I. Identification, purification, and properties.". J. Biol. Chem. 268 (34): 25587–93. PMID 8244996.
Pause A, Lee S, Worrell RA, et al. (1997). "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2156–61. PMID 9122164.
Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.". Genes Dev. 12 (19): 2992–6. PMID 9765201.
Zhang JG, Farley A, Nicholson SE, et al. (1999). "The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2071–6. PMID 10051596.
Stebbins CE, Kaelin WG, Pavletich NP (1999). "Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.". Science 284 (5413): 455–61. PMID 10205047.
Pause A, Peterson B, Schaffar G, et al. (1999). "Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9533–8. PMID 10449727.
Iwai K, Yamanaka K, Kamura T, et al. (1999). "Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12436–41. PMID 10535940.
Ohh M, Takagi Y, Aso T, et al. (2000). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.". J. Clin. Invest. 104 (11): 1583–91. PMID 10587522.
Aso T, Yamazaki K, Amimoto K, et al. (2000). "Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis.". J. Biol. Chem. 275 (9): 6546–52. PMID 10692460.
Kamura T, Sato S, Iwai K, et al. (2000). "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10430–5. doi:10.1073/pnas.190332597. PMID 10973499.
Aso T, Yamazaki K, Aigaki T, Kitajima S (2000). "Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity.". Biochem. Biophys. Res. Commun. 276 (1): 355–61. doi:10.1006/bbrc.2000.3451. PMID 11006129.
Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
Li Z, Na X, Wang D, et al. (2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein.". J. Biol. Chem. 277 (7): 4656–62. doi:10.1074/jbc.M108269200. PMID 11739384.
Yamazaki K, Guo L, Sugahara K, et al. (2002). "Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3.". J. Biol. Chem. 277 (29): 26444–51. doi:10.1074/jbc.M202859200. PMID 11994304.
Min JH, Yang H, Ivan M, et al. (2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.". Science 296 (5574): 1886–9. doi:10.1126/science.1073440. PMID 12004076.
Hon WC, Wilson MI, Harlos K, et al. (2002). "Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.". Nature 417 (6892): 975–8. doi:10.1038/nature00767. PMID 12050673.