TCEAL1

From Wikipedia, the free encyclopedia

Transcription elongation factor A (SII)-like 1

Identifiers

TCEAL1; SIIR; p21; pp21

External IDs

OMIM: 300237 MGI: 2385317 HomoloGene: 3510

Gene ontology
Molecular Function:	• transcription factor activity • RNA polymerase II transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001006639 (mRNA)
NP_001006640 (protein)

NM_146236 (mRNA)
NP_666348 (protein)

Location

Chr X: 102.77 - 102.77 Mb

Chr X: 132.05 - 132.06 Mb

Pubmed search

[1]

[2]

Transcription elongation factor A (SII)-like 1, also known as TCEAL1, is a human gene.^[1]

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.^[1]

[edit] References

^ ^a ^b Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1.

[edit] Further reading

Yeh CH, Zong WX, Shatkin AJ (1995). "The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression.". J. Biol. Chem. 270 (43): 25313-5. PMID 7592688.
Yeh CH, Shatkin AJ (1994). "Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11002-6. PMID 7971997.
Yeh CH, Shatkin AJ (1994). "A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII.". Gene 143 (2): 285-7. PMID 8206389.
Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (1999). "Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR.". Genomics 56 (2): 217-20. doi:10.1006/geno.1998.5705. PMID 10051408.
van der Kuip H, Carius B, Haque SJ, et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins.". J. Mol. Med. 77 (4): 386-92. PMID 10353443.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Makino H, Tajiri T, Miyashita M, et al. (2005). "Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis.". Dis. Esophagus 18 (1): 37-40. doi:10.1111/j.1442-2050.2005.00432.x. PMID 15773840.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942-54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.