TBL3

From Wikipedia, the free encyclopedia

Transducin (beta)-like 3

Identifiers

TBL3; SAZD

External IDs

OMIM: 605915 MGI: 2384863 HomoloGene: 4711

Gene ontology
Molecular Function:	• receptor signaling protein activity
Cellular Component:	• nucleus
Biological Process:	• G-protein signaling, coupled to cGMP nucleotide second messenger

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_006453 (mRNA)
NP_006444 (protein)

NM_145396 (mRNA)
NP_663371 (protein)

Location

Chr 16: 1.96 - 1.97 Mb

Chr 17: 24.43 - 24.44 Mb

Pubmed search

[1]

[2]

Transducin (beta)-like 3, also known as TBL3, is a human gene.^[1]

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet.^[1]

[edit] References

^ ^a ^b Entrez Gene: TBL3 transducin (beta)-like 3.

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100-9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298.
Weinstat-Saslow DL, Germino GG, Somlo S, Reeders ST (1994). "A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region.". Genomics 18 (3): 709-11. PMID 8307582.