Taxadien-5alpha-ol O-acetyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a taxadien-5alpha-ol O-acetyltransferase (EC 2.3.1.162) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + taxa-4(20),11-dien-5alpha-ol CoA + taxa-4(20),11-dien-5alpha-yl acetate

Thus, the two substrates of this enzyme are acetyl-CoA and taxa-4(20),11-dien-5alpha-ol, whereas its two products are CoA and taxa-4(20),11-dien-5alpha-yl acetate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase. Other names in common use include acetyl coenzyme A:taxa-4(20),11(12)-dien-5alpha-ol O-acetyl, and transferase. This enzyme participates in diterpenoid biosynthesis.

[edit] References

• IUBMB entry for 2.3.1.162
• BRENDA references for 2.3.1.162 (Recommended.)
• PubMed references for 2.3.1.162
• PubMed Central references for 2.3.1.162
• Google Scholar references for 2.3.1.162
• A, Croteau R (1999). "Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis". Arch. Biochem. Biophys. 364: 273–9. doi:10.1006/abbi.1999.1125. PMID 10190984. 

[edit] External links

The CAS registry number for this enzyme class is 229032-29-5.

• IUBMB entry for 2.3.1.162

• KEGG entry for 2.3.1.162

• BRENDA entry for 2.3.1.162

• NiceZyme view of 2.3.1.162

• EC2PDB: PDB structures for 2.3.1.162

• PRIAM entry for 2.3.1.162

• PUMA2 entry for 2.3.1.162

• IntEnz: Integrated Enzyme entry for 2.3.1.162

• MetaCyc entry for 2.3.1.162

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050638: taxadien-5-alpha-ol O-acetyltransferase

• AMIGO entry for GO code 0050638: taxadien-5-alpha-ol O-acetyltransferase