TASP1

From Wikipedia, the free encyclopedia

Taspase, threonine aspartase, 1

PDB rendering based on 2a8i.

Available structures: 2a8i, 2a8j, 2a8l, 2a8m

Identifiers

Symbol(s)

TASP1; C20orf13; FLJ20212; MGC39159; dJ585I14.2

External IDs

OMIM: 608270 MGI: 1923062 HomoloGene: 9795

Gene ontology
Molecular Function:	• asparaginase activity • threonine endopeptidase activity • peptidase activity
Biological Process:	• glycoprotein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017714 (mRNA)
NP_060184 (protein)

XM_991110 (mRNA)
XP_996204 (protein)

Location

Chr 20: 13.32 - 13.57 Mb

Chr 2: 139.53 - 139.76 Mb

Pubmed search

[1]

[2]

Taspase, threonine aspartase, 1, also known as TASP1, is a human gene.^[1]

This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: TASP1 taspase, threonine aspartase, 1.

[edit] Further reading

Zhou H, Spicuglia S, Hsieh JJ, et al. (2006). "Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.". Mol. Cell. Biol. 26 (7): 2728-35. doi:10.1128/MCB.26.7.2728-2735.2006. PMID 16537915.
Khan JA, Dunn BM, Tong L (2006). "Crystal structure of human Taspase1, a crucial protease regulating the function of MLL.". Structure 13 (10): 1443-52. doi:10.1016/j.str.2005.07.006. PMID 16216576.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Hsieh JJ, Cheng EH, Korsmeyer SJ (2004). "Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.". Cell 115 (3): 293-303. PMID 14636557.
Hsieh JJ, Ernst P, Erdjument-Bromage H, et al. (2003). "Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.". Mol. Cell. Biol. 23 (1): 186-94. PMID 12482972.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.