Tagatose-bisphosphate aldolase

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In enzymology, a tagatose-bisphosphate aldolase (EC 4.1.2.40) is an enzyme that catalyzes the chemical reaction

D-tagatose 1,6-bisphosphate $\rightleftharpoons$ glycerone phosphate + D-glyceraldehyde 3-phosphate

Hence, this enzyme has one substrate, D-tagatose 1,6-bisphosphate, and two products, glycerone phosphate and D-glyceraldehyde 3-phosphate.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is D-tagatose 1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming). This enzyme is also called D-tagatose-1,6-bisphosphate triosephosphate lyase. This enzyme participates in galactose metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GVF.

[edit] References

IUBMB entry for 4.1.2.40
BRENDA references for 4.1.2.40 (Recommended.)
PubMed references for 4.1.2.40
PubMed Central references for 4.1.2.40
Google Scholar references for 4.1.2.40
Anderson RL, Markwell JP (1982). "D-Tagatose-1,6-bisphosphate aldolase (Class II) from Klebsiella pneumoniae". Methods Enzymol. 90: 323–324.
van Rooijen RJ, van Schalkwijk S, de Vos WM (1991). "Molecular cloning, characterization, and nucleotide sequence of the tagatose 6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactis". J. Biol. Chem. 266: 7176–81. PMID 1901863.