TACC3

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Transforming, acidic coiled-coil containing protein 3
Identifiers
Symbol(s) TACC3; ERIC1; MGC117382; MGC133242
External IDs OMIM: 605303 MGI: 1341163 HomoloGene: 81618
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10460 21335
Ensembl ENSG00000013810 n/a
Uniprot Q9Y6A5 n/a
Refseq NM_006342 (mRNA)
NP_006333 (protein)		 NM_011524 (mRNA)
NP_035654 (protein)
Location Chr 4: 1.69 - 1.72 Mb n/a
Pubmed search [1] [2]

Transforming, acidic coiled-coil containing protein 3, also known as TACC3, is a human gene.[1]

The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice.[1]

[edit] References

  1. ^ a b Entrez Gene: TACC3 transforming, acidic coiled-coil containing protein 3.

[edit] Further reading

  • Lappin TR, Mullan RN, Stewart JP, et al. (2003). "AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains.". Leuk. Lymphoma 43 (7): 1455–9. PMID 12389629. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines.". Genomics 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID 10366448. 
  • Gergely F, Karlsson C, Still I, et al. (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi:10.1073/pnas.97.26.14352. PMID 11121038. 
  • McKeveney PJ, Hodges VM, Mullan RN, et al. (2001). "Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells.". Br. J. Haematol. 112 (4): 1016–24. PMID 11298601. 
  • Piekorz RP, Hoffmeyer A, Duntsch CD, et al. (2002). "The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis.". EMBO J. 21 (4): 653–64. PMID 11847113. 
  • Steadman BT, Schmidt PH, Shanks RA, et al. (2002). "Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus.". J. Biol. Chem. 277 (33): 30165–76. doi:10.1074/jbc.M201914200. PMID 12015314. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sadek CM, Pelto-Huikko M, Tujague M, et al. (2004). "TACC3 expression is tightly regulated during early differentiation.". Gene Expr. Patterns 3 (2): 203–11. PMID 12711550. 
  • Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing.". Biochem. Biophys. Res. Commun. 308 (4): 793–801. PMID 12927788. 
  • Gangisetty O, Lauffart B, Sondarva GV, et al. (2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.". Oncogene 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
  • Schneider L, Essmann F, Kletke A, et al. (2007). "The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival.". J. Biol. Chem. 282 (40): 29273–83. doi:10.1074/jbc.M704151200. PMID 17675670. 
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