TACC2

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Transforming, acidic coiled-coil containing protein 2
Identifiers
Symbol(s) TACC2; AZU-1; ECTACC
External IDs OMIM: 605302 MGI: 1928899 HomoloGene: 5087
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10579 57752
Ensembl ENSG00000138162 ENSMUSG00000030852
Uniprot O95359 Q5DTJ3
Refseq NM_006997 (mRNA)
NP_008928 (protein)		 NM_001004468 (mRNA)
NP_001004468 (protein)
Location Chr 10: 123.74 - 124 Mb Chr 7: 130.37 - 130.56 Mb
Pubmed search [1] [2]

Transforming, acidic coiled-coil containing protein 2, also known as TACC2, is a human gene.[1]

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.[1]

[edit] References

  1. ^ a b Entrez Gene: TACC2 transforming, acidic coiled-coil containing protein 2.

[edit] Further reading

  • Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines.". Genomics 58 (2): 165-70. doi:10.1006/geno.1999.5829. PMID 10366448. 
  • Still IH, Hamilton M, Vince P, et al. (1999). "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon.". Oncogene 18 (27): 4032-8. doi:10.1038/sj.onc.1202801. PMID 10435627. 
  • Gergely F, Kidd D, Jeffers K, et al. (2000). "D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo.". EMBO J. 19 (2): 241-52. doi:10.1093/emboj/19.2.241. PMID 10637228. 
  • Chen HM, Schmeichel KL, Mian IS, et al. (2000). "AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression.". Mol. Biol. Cell 11 (4): 1357-67. PMID 10749935. 
  • Gergely F, Karlsson C, Still I, et al. (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352-7. doi:10.1073/pnas.97.26.14352. PMID 11121038. 
  • Pu JJ, Li C, Rodriguez M, Banerjee D (2001). "Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells.". Cytokine 13 (3): 129-37. doi:10.1006/cyto.2000.0812. PMID 11161455. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lauffart B, Gangisetty O, Still IH (2003). "Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2.". Genomics 81 (2): 192-201. PMID 12620397. 
  • Sadek CM, Pelto-Huikko M, Tujague M, et al. (2004). "TACC3 expression is tightly regulated during early differentiation.". Gene Expr. Patterns 3 (2): 203-11. PMID 12711550. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gangisetty O, Lauffart B, Sondarva GV, et al. (2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.". Oncogene 23 (14): 2559-63. doi:10.1038/sj.onc.1207424. PMID 14767476. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054. 
  • Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P (2004). "Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms.". BMC Evol. Biol. 4: 16. doi:10.1186/1471-2148-4-16. PMID 15207008. 
  • Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2.". FEBS Lett. 572 (1-3): 51-6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243. 
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