TAC4

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Tachykinin 4 (hemokinin)
Identifiers
Symbol(s) TAC4; EK; HK-1; MGC133009; MGC133010; PPT-C
External IDs OMIM: 607833 HomoloGene: 89219
Orthologs
Human Mouse
Entrez 255061 n/a
Ensembl ENSG00000176358 n/a
Refseq NM_001077503 (mRNA)
NP_001070971 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 17: 45.27 - 45.28 Mb n/a
Pubmed search [1] n/a

Tachykinin 4 (hemokinin), also known as TAC4, is a human gene.[1]

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: TAC4 tachykinin 4 (hemokinin).

[edit] Further reading

  • Page NM (2007). "Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides.". Vascul. Pharmacol. 45 (4): 200–8. doi:10.1016/j.vph.2005.08.028. PMID 16931167. 
  • Page NM (2004). "Hemokinins and endokinins.". Cell. Mol. Life Sci. 61 (13): 1652–63. doi:10.1007/s00018-004-4035-x. PMID 15224188. 
  • Cunningham S, O'Doherty C, Patterson C, et al. (2007). "The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis.". J. Neuroimmunol. 183 (1-2): 208–13. doi:10.1016/j.jneuroim.2006.11.002. PMID 17175032. 
  • Page NM, Bell NJ, Gardiner SM, et al. (2003). "Characterization of the endokinins: human tachykinins with cardiovascular activity.". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6245–50. doi:10.1073/pnas.0931458100. PMID 12716968. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kurtz MM, Wang R, Clements MK, et al. (2003). "Identification, localization and receptor characterization of novel mammalian substance P-like peptides.". Gene 296 (1-2): 205–12. PMID 12383518. 
  • Bellucci F, Carini F, Catalani C, et al. (2002). "Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.". Br. J. Pharmacol. 135 (1): 266–74. doi:10.1038/sj.bjp.0704443. PMID 11786503. 
  • Zhang Y, Lu L, Furlonger C, et al. (2001). "Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis.". Nat. Immunol. 1 (5): 392–7. doi:10.1038/80826. PMID 11062498. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800. 
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