SYT7

From Wikipedia, the free encyclopedia

Synaptotagmin VII

PDB rendering based on 2d8k.

Available structures: 2d8k

Identifiers

Symbol(s)

SYT7; IPCA-7; MGC150517; PCANAP7; SYT-VII

External IDs

OMIM: 604146 MGI: 1859545 HomoloGene: 20889

Gene ontology
Molecular Function:	• transporter activity • calcium ion binding
Cellular Component:	• lysosome • synaptic vesicle • membrane • integral to membrane • synapse
Biological Process:	• plasma membrane repair • transport

Orthologs

Human

Mouse

Refseq

XM_943686 (mRNA)
XP_948779 (protein)

NM_018801 (mRNA)
NP_061271 (protein)

Location

Chr 11: 61.04 - 61.1 Mb

Chr 19: 10.46 - 10.52 Mb

Pubmed search

[1]

[2]

Synaptotagmin VII, also known as SYT7, is a human gene.^[1]

Synaptotagmins, such as SYT7, are brain-specific calcium-dependent phospholipid-binding proteins that play a role in synaptic exocytosis and neurotransmitter release. See MIM 600782.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SYT7 synaptotagmin VII.

[edit] Further reading

Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.". Nature 375 (6532): 594-9. doi:10.1038/375594a0. PMID 7791877.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.". Biochemistry 35 (43): 13808-16. doi:10.1021/bi960853x. PMID 8901523.
Cooper PR, Nowak NJ, Higgins MJ, et al. (1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes.". Genomics 49 (3): 419-29. doi:10.1006/geno.1998.5291. PMID 9615227.
Craxton M, Goedert M (1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping.". FEBS Lett. 460 (3): 417-22. PMID 10556508.
Walker MG, Volkmuth W, Sprinzak E, et al. (2000). "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes.". Genome Res. 9 (12): 1198-203. PMID 10613842.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.". J. Biol. Chem. 275 (13): 9823-31. PMID 10734137.
Caler EV, Chakrabarti S, Fowler KT, et al. (2001). "The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi.". J. Exp. Med. 193 (9): 1097-104. PMID 11342594.
Fukuda M, Ogata Y, Saegusa C, et al. (2002). "Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human.". Biochem. J. 365 (Pt 1): 173-80. doi:10.1042/BJ20011877. PMID 12071850.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.