SYT6

From Wikipedia, the free encyclopedia

Synaptotagmin VI

Identifiers

External IDs

OMIM: 607718 MGI: 1859544 HomoloGene: 10301

Gene ontology
Molecular Function:	• transporter activity • calcium ion binding
Cellular Component:	• synaptic vesicle • membrane • integral to membrane • synapse
Biological Process:	• transport

Orthologs

Human

Mouse

Refseq

NM_205848 (mRNA)
NP_995320 (protein)

NM_018800 (mRNA)
NP_061270 (protein)

Location

Chr 1: 114.43 - 114.5 Mb

Chr 3: 103.7 - 103.77 Mb

Pubmed search

[1]

[2]

Synaptotagmin VI, also known as SYT6, is a human gene.^[1]

Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SYT6 synaptotagmin VI.

[edit] Further reading

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Roggero CM, Tomes CN, De Blas GA, et al. (2006). "Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis.". Dev. Biol. 285 (2): 422-35. doi:10.1016/j.ydbio.2005.07.007. PMID 16111671.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Craxton M (2001). "Genomic analysis of synaptotagmin genes.". Genomics 77 (1-2): 43-9. doi:10.1006/geno.2001.6619. PMID 11543631.
Michaut M, De Blas G, Tomes CN, et al. (2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa.". Dev. Biol. 235 (2): 521-9. doi:10.1006/dbio.2001.0316. PMID 11437455.
Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.". Biochemistry 35 (43): 13808-16. doi:10.1021/bi960853x. PMID 8901523.
Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.". Nature 375 (6532): 594-9. doi:10.1038/375594a0. PMID 7791877.