SYMPK

From Wikipedia, the free encyclopedia

Symplekin

Identifiers

SYMPK; FLJ27092; SPK; SYM

External IDs

OMIM: 602388 MGI: 1915438 HomoloGene: 37969

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• nucleus • nucleoplasm • cytoplasm • tight junction
Biological Process:	• cell adhesion • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004819 (mRNA)
NP_004810 (protein)

XM_485873 (mRNA)
XP_485873 (protein)

Location

Chr 19: 51.01 - 51.06 Mb

Chr 7: 18.18 - 18.21 Mb

Pubmed search

[1]

[2]

Symplekin, also known as SYMPK, is a human gene.^[1]

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.^[1]

[edit] References

^ ^a ^b Entrez Gene: SYMPK symplekin.

[edit] Further reading

Keon BH, Schäfer S, Kuhn C, et al. (1996). "Symplekin, a novel type of tight junction plaque protein.". J. Cell Biol. 134 (4): 1003-18. PMID 8769423.
Ueki K, Ramaswamy S, Billings SJ, et al. (1997). "Chromosomal localization to 19q13.3, partial genomic structure and 5' cDNA sequence of the human symplekin gene.". Somat. Cell Mol. Genet. 23 (3): 229-31. PMID 9330635.
Alwazzan M, Hamshere MG, Lennon GG, Brook JD (1998). "Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat.". Mamm. Genome 9 (6): 485-7. PMID 9585442.
Faber PW, Barnes GT, Srinidhi J, et al. (1998). "Huntingtin interacts with a family of WW domain proteins.". Hum. Mol. Genet. 7 (9): 1463-74. PMID 9700202.
Paffenholz R, Kuhn C, Grund C, et al. (1999). "The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction.". Exp. Cell Res. 250 (2): 452-64. doi:10.1006/excr.1999.4534. PMID 10413599.
Takagaki Y, Manley JL (2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component.". Mol. Cell. Biol. 20 (5): 1515-25. PMID 10669729.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304-51. doi:10.1126/science.1058040. PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Langbein L, Pape UF, Grund C, et al. (2004). "Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas.". Eur. J. Cell Biol. 82 (8): 385-400. PMID 14533737.
Xing H, Mayhew CN, Cullen KE, et al. (2004). "HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin.". J. Biol. Chem. 279 (11): 10551-5. doi:10.1074/jbc.M311719200. PMID 14707147.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Barnard DC, Ryan K, Manley JL, Richter JD (2005). "Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.". Cell 119 (5): 641-51. doi:10.1016/j.cell.2004.10.029. PMID 15550246.
Kolev NG, Steitz JA (2006). "Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs.". Genes Dev. 19 (21): 2583-92. doi:10.1101/gad.1371105. PMID 16230528.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Kavanagh E, Buchert M, Tsapara A, et al. (2007). "Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin.". J. Cell. Sci. 119 (Pt 24): 5098-105. doi:10.1242/jcs.03297. PMID 17158914.