SV2A

From Wikipedia, the free encyclopedia

Synaptic vesicle glycoprotein 2A

Identifiers

SV2A; KIAA0736; SV2

External IDs

OMIM: 185860 MGI: 1927139 HomoloGene: 32237

Gene ontology
Molecular Function:	• transporter activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane • synapse
Biological Process:	• neurotransmitter transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014849 (mRNA)
NP_055664 (protein)

NM_022030 (mRNA)
NP_071313 (protein)

Location

Chr 1: 148.14 - 148.16 Mb

Chr 3: 96.27 - 96.28 Mb

Pubmed search

[1]

[2]

Synaptic vesicle glycoprotein 2A, also known as SV2A, is a human gene.^[1]

[edit] References

^ Entrez Gene: SV2A synaptic vesicle glycoprotein 2A.

[edit] Further reading

Bajjalieh SM, Peterson K, Shinghal R, Scheller RH (1992). "SV2, a brain synaptic vesicle protein homologous to bacterial transporters.". Science 257 (5074): 1271–3. PMID 1519064.
Bajjalieh SM, Peterson K, Linial M, Scheller RH (1993). "Brain contains two forms of synaptic vesicle protein 2.". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2150–4. PMID 7681585.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Crowder KM, Gunther JM, Jones TA, et al. (2000). "Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A).". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 15268–73. PMID 10611374.
Son YJ, Scranton TW, Sunderland WJ, et al. (2000). "The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.". J. Biol. Chem. 275 (1): 451–60. PMID 10617638.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lynch BA, Lambeng N, Nocka K, et al. (2004). "The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.". Proc. Natl. Acad. Sci. U.S.A. 101 (26): 9861–6. doi:10.1073/pnas.0308208101. PMID 15210974.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex.". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.