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Contents 1 Page in mess!!! 2 Naming 2.1 Tom Clancy's "Teeth of the Tiger" 2.2 History 2.3 Some thoughts 2.4 He's right 2.5 Butyrylcholinesterase and the Nicotinic ACh receptor 3 Side Effects

[edit] Page in mess!!!

This page introduces total confusion between succinylcholine and its chloride. Those two MUST BE SEPARATED! Either there is a chlorine in the molecule or not, the name must reflect it! This looks like a major rework or redirects, etc. I leave then only an alert here. Sometimes Wikipedia is scary!

I have tagged the article accordingly. By the way, for future reference, please sign your comments. Thank you for the feedback. 38.100.34.2 17:18, 28 March 2007 (UTC)

As far as I know, succinylcholine is presented with chloride as a counterion to maintain neutrality, as it is a charged molecule. Is there anything else you feel could be improved on this page? I would appreciate more feedback. Fvasconcellos 00:40, 3 April 2007 (UTC)

[edit] Naming

One dose frequently used in clinical practice is 2 mg/kg. (At least that is the dose I usually use in my clinical practice). John Doyle. (djdoyle)

I guess the substance under discussion is Succinylbischoline (with a "bis" in it) aka Suxamethonium. I´m not entirely sure which of the two is correct so I won´t change it right now. Could somebody please check the proper pharmacological name? Kosebamse 12:54 Jan 28, 2003 (UTC)

I think the only "proper" name is the IUPAC chemical name, which is not in everyday use. Suxamethonium, scoline, and succinylcholine seem to be the commonest names this compound is referred by - Malcolm Farmer

I looked it up in a pharmacology textbook and the substance is listed under succinylbischoline (with a bis). But it's true that in everyday use it is succinylcholine (without a bis) or even succi so I really don't know where it should properly go. With hypertext however I believe it might be feasible to have substances dealt with under their IUPAC name and have common names linked there. Perhaps there is a wikipedia policy for this? Kosebamse

My pharm book has it listed as Succinylcholine. My vote on the "proper" name would be the International Nonproprietary Name which is set by the WHO. I don't know if Succinylcholine is the INN or the USAN (My book is american).Matt 04:38, 23 Jun 2004 (UTC)

It seems that the INN is suxamethonium chloride with CAS no. 71-27-2.

Far more common than malignant hyperthermia and prolonged block is anaphylaxis. I thought that it was implicated in anaphylaxis more than any other anaesthetic drug and that this was the leading cause of death due to it's use. Should we not edit the page to reflect this in the side effect paragraph?

Go ahead. Do you have incidence figures. JFW | T@lk 10:59, 23 October 2005 (UTC)

[edit] Tom Clancy's "Teeth of the Tiger"

This drug--spelled succinylcholine throughout the book--is used to assassinate several "bad guys" in Clancy's 2003 novel Teeth of the Tiger, though the symptoms and speed of death (cardiac arrest) vary somewhat from the description in the article. --Robertkeller 23:28, 11 September 2006 (UTC)

I'd trust Clancy before wiki, I mean Clancy knows his shit, CIA doesn't let dumbies lecture at Langley. Supra guy 07:25, 22 July 2007 (UTC)

Except that death is not invariably a result if sux administration, as he suggests. The effects don't last long enough in most patients to cause hypoxic myocardial death. I'm not saying it can't happen, just that it's nothing like as reliable as portrayed. Dlh-stablelights (talk) 11:49, 30 January 2008 (UTC)

[edit] History

A nice, freely accessible review which may help with the writing of a "History" section. Fvasconcellos 01:12, 3 April 2007 (UTC)

[edit] Some thoughts

I am not an expert but as far as I am aware Phase 2 block does not normally occur with suxamethonium at normal doses. It occurs when repeated doses of sux are given. Also, talking about the "anaesthetic effects" of sux (in the same Phase 2 paragraph) is not really accurate, as sux is a neuromuscular blocker, not an anaesthetic. Also talking about an endplate potential less than the action potential (as mentioned in the Phase 1 paragraph) does not really make sense either. I would get stuck in right now but haven't got the time. I have removed the drug doses though as wiki shouldn't be giving drug doses (vandals might cause great harm.) I'll come back when I've got a bit more spare time.Mmoneypenny 13:36, 17 April 2007 (UTC)

[edit] He's right

The description given in the article as 'phase 2 block' is actually phase 1 block; phase 2 block generally occurs with repeated administration/overdose. The two can be distinguished using a nerve stimulator. Sorry I don't have time to rewrite the section at the moment but any textbook of anaesthetics/ anaesthetic pharmacology will confirm this. Johnhglen (talk) 09:05, 22 December 2007 (UTC)

Righto; I have editted the 'Phase 1 Block' / 'Phase 2 Block' Section. I forgot to login, so it is under an IP address, but it was me. The section can still benefit from some cleaning up; not everything is linked; specifically a link to normal muscle depolarisation would probbly be appropriate and may cut down some of the text. Cheers, Maniaccs2 (talk) 01:23, 7 January 2008 (UTC)

[edit] Butyrylcholinesterase and the Nicotinic ACh receptor

Butyrylcholinesterase and pseudocholinesterase are the same thing, but butyrylcholinesterase is 'more' correct (more recent) and actually has a wiki page.

The ACh Nicotinic receptor is a ligand gated Sodium Channel. I agree some potassium probably leaks through but it is not widely accepted, nor labeled as a Sodium/Potassium Channel. If you are going to attempt to change it back please provide a reference. Maniaccs2 (talk) 14:18, 7 February 2008 (UTC)

[edit] Side Effects

I would argue Suxamethonium is never given to conscious patients, even in emergency situations. It is simple enough to provide even mild sedation and amnesia with concurrent agents. (But I haven't changed this statement on the wiki). Maniaccs2 (talk) 14:23, 7 February 2008 (UTC)