Survival of motor neuron protein-interacting protein 1

From Wikipedia, the free encyclopedia

Survival of motor neuron protein interacting protein 1

Identifiers

SIP1; GEMIN2; SIP1-delta

External IDs

OMIM: 602595 MGI: 1913853 HomoloGene: 37827

Gene ontology
Molecular Function:	• protein binding • RNA splicing factor activity, transesterification mechanism
Cellular Component:	• nucleus • spliceosome • cytoplasm
Biological Process:	• spliceosome assembly • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001009182 (mRNA)
NP_001009182 (protein)

NM_025656 (mRNA)
NP_079932 (protein)

Location

Chr 14: 38.65 - 38.68 Mb

Chr 12: 59.93 - 59.95 Mb

Pubmed search

[1]

[2]

Survival of motor neuron protein interacting protein 1, also known as SIP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1.

[edit] Further reading

Wang Z, Wu X, Friedberg EC (1997). "Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts.". J. Biol. Chem. 272 (38): 24064–71. PMID 9295360.
Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.". Cell 90 (6): 1013–21. PMID 9323129.
Fischer U, Liu Q, Dreyfuss G (1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis.". Cell 90 (6): 1023–9. PMID 9323130.
Zhang WJ, Wu JY (1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.". Mol. Cell. Biol. 18 (2): 676–84. PMID 9447963.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems.". J. Cell Biol. 147 (6): 1181–94. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.". J. Cell Biol. 148 (6): 1177–86. PMID 10725331.
Helmken C, Wetter A, Rudnik-Schöneborn S, et al. (2000). "An essential SMN interacting protein (SIP1) is not involved in the phenotypic variability of spinal muscular atrophy (SMA).". Eur. J. Hum. Genet. 8 (7): 493–9. doi:10.1038/sj.ejhg.5200479. PMID 10909848.
Meister G, Bühler D, Laggerbauer B, et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins.". Hum. Mol. Genet. 9 (13): 1977–86. PMID 10942426.
Young PJ, Man NT, Lorson CL, et al. (2001). "The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding.". Hum. Mol. Genet. 9 (19): 2869–77. PMID 11092763.
Selenko P, Sprangers R, Stier G, et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins.". Nat. Struct. Biol. 8 (1): 27–31. doi:10.1038/83014. PMID 11135666.
Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A functional interaction between the survival motor neuron complex and RNA polymerase II.". J. Cell Biol. 152 (1): 75–85. PMID 11149922.
Jablonka S, Bandilla M, Wiese S, et al. (2001). "Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy.". Hum. Mol. Genet. 10 (5): 497–505. PMID 11181573.
Friesen WJ, Massenet S, Paushkin S, et al. (2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets.". Mol. Cell 7 (5): 1111–7. PMID 11389857.
Park JW, Voss PG, Grabski S, et al. (2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein.". Nucleic Acids Res. 29 (17): 3595–602. PMID 11522829.
Friesen WJ, Paushkin S, Wyce A, et al. (2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMID 11713266.
Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins.". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component.". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Aerbajinai W, Ishihara T, Arahata K, Tsukahara T (2002). "Increased expression level of the splicing variant of SIP1 in motor neuron diseases.". Int. J. Biochem. Cell Biol. 34 (6): 699–707. PMID 11943600.
Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex.". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.