Surfactant protein C
From Wikipedia, the free encyclopedia
| Surfactant-associated polypeptide | ||
|---|---|---|
| Identifiers | ||
| Symbol | Pulm_surfact_AP | |
| InterPro | IPR001729 | |
| SMART | SF_P | |
| PROSITE | PDOC00298 | |
| Available PDB structures:
1spf :1-35 |
||
| Surfactant protein C, N terminal propeptide | ||
|---|---|---|
| Identifiers | ||
| Symbol | SP_C-Propep | |
| Pfam | PF08999 | |
| InterPro | IPR015091 | |
| OPM protein | 1spf | |
| Available PDB structures:
1spf :1-35 |
||
|
surfactant, pulmonary-associated protein C
|
|
| Identifiers | |
| Symbol | SFTPC |
| Alt. Symbols | SFTP2 |
| Entrez | 6440 |
| HUGO | 10802 |
| OMIM | 178620 |
| RefSeq | NM_003018 |
| UniProt | P11686 |
| Other data | |
| Locus | Chr. 8 p21 |
The N-terminal propeptide of surfactant protein C adopts an alpha-helical structure, with turn and extended regions. Its main function is the stabilisation of metastable surfactant protein C (SP-C), since the latter can irreversibly transform from its native alpha-helical structure to beta- sheet aggregates and form amyloid-like fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide[1].
[edit] References
- ^ Li J, Jornvall H, Johansson J, Curstedt T, Liepinsh E, Almlen A, Thyberg J (2006). "Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C". FEBS J 273 (5): -. doi:. PMID 16478467.
[edit] See also
[edit] External links
This article includes text from the public domain Pfam and InterPro IPR015091
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
