SURF4

From Wikipedia, the free encyclopedia

Surfeit 4

Identifiers

SURF4; ERV29; FLJ22993; MGC102753

External IDs

OMIM: 185660 MGI: 98445 HomoloGene: 6052

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• endoplasmic reticulum • ER-Golgi intermediate compartment • membrane • integral to membrane
Biological Process:	• biological_process

Orthologs

Human

Mouse

Refseq

NM_033161 (mRNA)
NP_149351 (protein)

NM_011512 (mRNA)
NP_035642 (protein)

Location

Chr 9: 135.21 - 135.23 Mb

Chr 2: 26.74 - 26.76 Mb

Pubmed search

[1]

[2]

Surfeit 4, also known as SURF4, is a human gene.^[1]

This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). The specific function of this protein has not been determined but its yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles. This gene uses multiple polyadenylation sites, resulting in transcript length variation. The existence of alternatively spliced transcript variants has been suggested, but their validity has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: SURF4 surfeit 4.

[edit] Further reading

Reeves JE, Fried M (1995). "The surf-4 gene encodes a novel 30 kDa integral membrane protein.". Mol. Membr. Biol. 12 (2): 201-8. PMID 7540914.
Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1.". Hum. Mol. Genet. 2 (3): 237-40. PMID 8499913.
Duhig T, Ruhrberg C, Mor O, Fried M (1999). "The human Surfeit locus.". Genomics 52 (1): 72-8. doi:10.1006/geno.1998.5372. PMID 9740673.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543-8. doi:10.1073/pnas.160270997. PMID 10931946.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.". J. Biol. Chem. 279 (45): 47242-53. doi:10.1074/jbc.M406644200. PMID 15308636.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.