SULT1E1

From Wikipedia, the free encyclopedia


Sulfotransferase family 1E, estrogen-preferring, member 1
PDB rendering based on 1g3m.
Available structures: 1g3m, 1hy3
Identifiers
Symbol(s) SULT1E1; EST; EST-1; MGC34459; STE
External IDs OMIM: 600043 MGI: 98431 HomoloGene: 68469
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6783 20860
Ensembl ENSG00000109193 ENSMUSG00000029272
Uniprot P49888 Q8JZX7
Refseq NM_005420 (mRNA)
NP_005411 (protein)		 XM_976056 (mRNA)
XP_981150 (protein)
Location Chr 4: 70.74 - 70.76 Mb Chr 5: 88.65 - 88.67 Mb
Pubmed search [1] [2]

Sulfotransferase family 1E, estrogen-preferring, member 1, also known as SULT1E1, is a human gene.[1]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.[1]

[edit] References

  1. ^ a b Entrez Gene: SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1.

[edit] Further reading

  • Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.". FASEB J. 11 (1): 3–14. PMID 9034160. 
  • Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology.". Toxicol. Lett. 112-113: 341–8. PMID 10720750. 
  • Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics.". Chem. Biol. Interact. 129 (1-2): 141–70. PMID 11154739. 
  • Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.". Mutat. Res. 482 (1-2): 27–40. PMID 11535246. 
  • Falany CN, Krasnykh V, Falany JL (1995). "Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase.". J. Steroid Biochem. Mol. Biol. 52 (6): 529–39. PMID 7779757. 
  • Bernier F, Leblanc G, Labrie F, Luu-The V (1994). "Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene.". J. Biol. Chem. 269 (45): 28200–5. PMID 7961757. 
  • Aksoy IA, Wood TC, Weinshilboum R (1994). "Human liver estrogen sulfotransferase: identification by cDNA cloning and expression.". Biochem. Biophys. Res. Commun. 200 (3): 1621–9. doi:10.1006/bbrc.1994.1637. PMID 8185618. 
  • Her C, Aksoy IA, Kimura S, et al. (1996). "Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization.". Genomics 29 (1): 16–23. doi:10.1006/geno.1995.1210. PMID 8530066. 
  • Falany JL, Falany CN (1996). "Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines.". Cancer Res. 56 (7): 1551–5. PMID 8603401. 
  • Her C, Szumlanski C, Aksoy IA, Weinshilboum RM (1997). "Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation.". Drug Metab. Dispos. 24 (12): 1328–35. PMID 8971138. 
  • Song WC, Qian Y, Sun X, Negishi M (1997). "Cellular localization and regulation of expression of testicular estrogen sulfotransferase.". Endocrinology 138 (11): 5006–12. PMID 9348232. 
  • Rubin GL, Harrold AJ, Mills JA, et al. (1999). "Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy.". Mol. Hum. Reprod. 5 (11): 995–1002. PMID 10541560. 
  • Meinl W, Glatt H (2001). "Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene.". Biochem. Biophys. Res. Commun. 288 (4): 855–62. doi:10.1006/bbrc.2001.5829. PMID 11688987. 
  • Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M (2002). "Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction.". J. Biol. Chem. 277 (20): 17928–32. doi:10.1074/jbc.M111651200. PMID 11884392. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Shevtsov S, Petrotchenko EV, Pedersen LC, Negishi M (2003). "Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase.". Environ. Health Perspect. 111 (7): 884–8. PMID 12782487. 
 This article on a gene on chromosome 4 is a stub. You can help Wikipedia by expanding it.