SULT1A2

From Wikipedia, the free encyclopedia

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2

PDB rendering based on 1cjm.

Available structures: 1cjm, 1ls6, 1z28, 1z29, 2a3r, 2d06

Identifiers

Symbol(s)

SULT1A2; HAST4; MGC142287; MGC142289; P-PST; ST1A2; STP2; TSPST2

External IDs

OMIM: 601292 HomoloGene: 88641

Gene ontology
Molecular Function:	• aryl sulfotransferase activity • sulfotransferase activity • transferase activity
Biological Process:	• catecholamine metabolic process • lipid metabolic process • steroid metabolic process • amine biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001054 (mRNA)
NP_001045 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 16: 28.51 - 28.51 Mb

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Pubmed search

[1]

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Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2, also known as SULT1A2, is a human gene.^[1]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2.

[edit] Further reading

Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.". FASEB J. 11 (1): 3–14. PMID 9034160.
Windmill KF, Christiansen A, Teusner JT, et al. (1998). "Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry.". Chem. Biol. Interact. 109 (1-3): 341–6. PMID 9566757.
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology.". Toxicol. Lett. 112-113: 341–8. PMID 10720750.
Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics.". Chem. Biol. Interact. 129 (1-2): 141–70. PMID 11154739.
Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.". Mutat. Res. 482 (1-2): 27–40. PMID 11535246.
Ozawa S, Nagata K, Shimada M, et al. (1995). "Primary structures and properties of two related forms of aryl sulfotransferases in human liver.". Pharmacogenetics 5 Spec No: S135–40. PMID 7581483.
Yamazoe Y, Ozawa S, Nagata K, et al. (1995). "Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds.". Environ. Health Perspect. 102 Suppl 6: 99–103. PMID 7889867.
Yamazoe Y, Nagata K, Ozawa S, Kato R (1994). "Structural similarity and diversity of sulfotransferases.". Chem. Biol. Interact. 92 (1-3): 107–17. PMID 8033246.
Her C, Raftogianis R, Weinshilboum RM (1996). "Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization.". Genomics 33 (3): 409–20. doi:10.1006/geno.1996.0216. PMID 8661000.
Zhu X, Veronese ME, Iocco P, McManus ME (1996). "cDNA cloning and expression of a new form of human aryl sulfotransferase.". Int. J. Biochem. Cell Biol. 28 (5): 565–71. PMID 8697101.
Dooley TP, Huang Z (1996). "Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16.". Biochem. Biophys. Res. Commun. 228 (1): 134–40. doi:10.1006/bbrc.1996.1628. PMID 8912648.
Gaedigk A, Beatty BG, Grant DM (1997). "Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene.". Genomics 40 (2): 242–6. doi:10.1006/geno.1996.4575. PMID 9119390.
Harris RM, Waring RH, Kirk CJ, Hughes PJ (2000). "Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases.". J. Biol. Chem. 275 (1): 159–66. PMID 10617600.
Engelke CE, Meinl W, Boeing H, Glatt H (2000). "Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2.". Pharmacogenetics 10 (2): 163–9. PMID 10762004.
Carlini EJ, Raftogianis RB, Wood TC, et al. (2001). "Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects.". Pharmacogenetics 11 (1): 57–68. PMID 11207031.