SUFU

From Wikipedia, the free encyclopedia

Suppressor of fused homolog (Drosophila)

PDB rendering based on 1m1l.

Available structures: 1m1l

Identifiers

Symbol(s)

SUFU; PRO1280; SUFUH; SUFUXL

External IDs

OMIM: 607035 MGI: 1345643 HomoloGene: 9262

Gene ontology
Molecular Function:	• transcription corepressor activity • signal transducer activity • identical protein binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • skeletal development • regulation of transcription, DNA-dependent • proteolysis • cell cycle • signal transduction • multicellular organismal development • negative regulation of progression through cell cycle • negative regulation of smoothened signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016169 (mRNA)
NP_057253 (protein)

NM_001025391 (mRNA)
NP_001020562 (protein)

Location

Chr 10: 104.25 - 104.38 Mb

Chr 19: 46.45 - 46.54 Mb

Pubmed search

[1]

[2]

Suppressor of fused homolog (Drosophila), also known as SUFU, is a human gene.^[1]

SUFU encodes a component of the sonic hedgehog (SHH; MIM 600725)/patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SUFU suppressor of fused homolog (Drosophila).

[edit] Further reading

Kogerman P, Grimm T, Kogerman L, et al. (1999). "Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.". Nat. Cell Biol. 1 (5): 312–9. doi:10.1038/13031. PMID 10559945.
Stone DM, Murone M, Luoh S, et al. (2000). "Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.". J. Cell. Sci. 112 ( Pt 23): 4437–48. PMID 10564661.
Murone M, Luoh SM, Stone D, et al. (2000). "Gli regulation by the opposing activities of fused and suppressor of fused.". Nat. Cell Biol. 2 (5): 310–2. doi:10.1038/35010610. PMID 10806483.
Delattre M, Briand S, Paces-Fessy M, Blanchet-Tournier MF (2001). "The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals.". Dev. Genes Evol. 209 (5): 294–300. PMID 11252182.
Cheng SY, Bishop JM (2002). "Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5442–7. doi:10.1073/pnas.082096999. PMID 11960000.
Taylor MD, Liu L, Raffel C, et al. (2002). "Mutations in SUFU predispose to medulloblastoma.". Nat. Genet. 31 (3): 306–10. doi:10.1038/ng916. PMID 12068298.
Dunaeva M, Michelson P, Kogerman P, Toftgard R (2003). "Characterization of the physical interaction of Gli proteins with SUFU proteins.". J. Biol. Chem. 278 (7): 5116–22. doi:10.1074/jbc.M209492200. PMID 12426310.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Paces-Fessy M, Boucher D, Petit E, et al. (2004). "The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins.". Biochem. J. 378 (Pt 2): 353–62. doi:10.1042/BJ20030786. PMID 14611647.
Taylor MD, Zhang X, Liu L, et al. (2004). "Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.". Oncogene 23 (26): 4577–83. doi:10.1038/sj.onc.1207605. PMID 15077159.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Merchant M, Vajdos FF, Ultsch M, et al. (2004). "Suppressor of fused regulates Gli activity through a dual binding mechanism.". Mol. Cell. Biol. 24 (19): 8627–41. doi:10.1128/MCB.24.19.8627-8641.2004. PMID 15367681.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lyle R, Radhakrishna U, Blouin JL, et al. (2006). "Split-hand/split-foot malformation 3 (SHFM3) at 10q24, development of rapid diagnostic methods and gene expression from the region.". Am. J. Med. Genet. A 140 (13): 1384–95. doi:10.1002/ajmg.a.31247. PMID 16691619.