Succinylornithine transaminase

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In enzymology, a succinylornithine transaminase (EC 2.6.1.81) is an enzyme that catalyzes the chemical reaction

N₂-succinyl-L-ornithine + 2-oxoglutarate $\rightleftharpoons$ N-succinyl-L-glutamate 5-semialdehyde + L-glutamate

Thus, the two substrates of this enzyme are N2-succinyl-L-ornithine and 2-oxoglutarate, whereas its two products are N-succinyl-L-glutamate 5-semialdehyde and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase. Other names in common use include succinylornithine aminotransferase, N2-succinylornithine 5-aminotransferase, AstC, SOAT, and 2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase. This enzyme participates in arginine and proline metabolism.

[edit] References

IUBMB entry for 2.6.1.81
BRENDA references for 2.6.1.81 (Recommended.)
PubMed references for 2.6.1.81
PubMed Central references for 2.6.1.81
Google Scholar references for 2.6.1.81
Vander Wauven C, Stalon V (1985). "Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia". J. Bacteriol. 164: 882–6. PMID 2865249.
Schneider BL, Kiupakis AK, Reitzer LJ (1998). "Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli". J. Bacteriol. 180: 4278–86. PMID 9696779.
Cunin R, Glansdorff N, Pierard A, Stalon V (1986). "Biosynthesis and metabolism of arginine in bacteria". Microbiol. Rev. 50: 314–52. PMID 3534538.
Itoh Y (1997). "Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa". J. Bacteriol. 179: 7280–90. PMID 9393691.
Stalon V, Vander Wauven C, Momin P, Legrain C (1987). "Catabolism of arginine, citrulline and ornithine by Pseudomonas and related bacteria". J. Gen. Microbiol. 133: 2487–95. PMID 3129535.