SUB1

From Wikipedia, the free encyclopedia

SUB1 homolog (S. cerevisiae)

PDB rendering based on 1pcf.

Available structures: 1pcf, 2c62, 2phe

Identifiers

Symbol(s)

SUB1; p14; P15; PC4; MGC102747

External IDs

OMIM: 600503 MGI: 104811 HomoloGene: 38218

Gene ontology
Molecular Function:	• DNA binding • single-stranded DNA binding • transcription coactivator activity • protein binding
Cellular Component:	• nucleus • transcription factor complex
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006713 (mRNA)
NP_006704 (protein)

NM_011294 (mRNA)
NP_035424 (protein)

Location

Chr 5: 32.62 - 32.64 Mb

Chr 15: 11.93 - 11.94 Mb

Pubmed search

[1]

[2]

SUB1 homolog (S. cerevisiae), also known as SUB1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SUB1 SUB1 homolog (S. cerevisiae).

[edit] Further reading

Kaiser K, Stelzer G, Meisterernst M (1995). "The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation.". EMBO J. 14 (14): 3520–7. PMID 7628453.
Ge H, Zhao Y, Chait BT, Roeder RG (1995). "Phosphorylation negatively regulates the function of coactivator PC4.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12691–5. PMID 7809103.
Ge H, Roeder RG (1994). "Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes.". Cell 78 (3): 513–23. PMID 8062391.
Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M (1994). "A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators.". Cell 78 (3): 525–34. PMID 8062392.
Brandsen J, Werten S, van der Vliet PC, et al. (1997). "C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.". Nat. Struct. Biol. 4 (11): 900–3. PMID 9360603.
Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. PMID 9482861.
Luo Y, Ge H, Stevens S, et al. (1998). "Coactivation by OCA-B: definition of critical regions and synergism with general cofactors.". Mol. Cell. Biol. 18 (7): 3803–10. PMID 9632764.
Currie RA (1998). "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development.". J. Biol. Chem. 273 (29): 18220–9. PMID 9660784.
Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III.". Mol. Cell 1 (5): 749–57. PMID 9660958.
Holloway AF, Occhiodoro F, Mittler G, et al. (2000). "Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells.". J. Biol. Chem. 275 (28): 21668–77. doi:10.1074/jbc.M909058199. PMID 10887206.
Yuan CX, Gurley WB (2001). "Potential targets for HSF1 within the preinitiation complex.". Cell Stress Chaperones 5 (3): 229–42. PMID 11005381.
Kumar BR, Swaminathan V, Banerjee S, Kundu TK (2001). "p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation.". J. Biol. Chem. 276 (20): 16804–9. doi:10.1074/jbc.M100934200. PMID 11279157.
Yu P, Huang B, Shen M, et al. (2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues.". Oncogene 20 (4): 484–9. doi:10.1038/sj.onc.1204113. PMID 11313979.
Calvo O, Manley JL (2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination.". Mol. Cell 7 (5): 1013–23. PMID 11389848.
Guo H, Cai CQ, Kuo PC (2002). "Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription.". J. Biol. Chem. 277 (7): 5054–60. doi:10.1074/jbc.M109017200. PMID 11741883.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Dubois T, Zemlickova E, Howell S, Aitken A (2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin.". Biochem. Biophys. Res. Commun. 301 (2): 502–8. PMID 12565890.
Fukuda A, Tokonabe S, Hamada M, et al. (2003). "Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH.". J. Biol. Chem. 278 (17): 14827–31. doi:10.1074/jbc.M213172200. PMID 12590132.
Swietlicki E, Iordanov H, Fritsch C, et al. (2003). "Growth factor regulation of PC4/TIS7, an immediate early gene expressed during gut adaptation after resection.". JPEN. Journal of parenteral and enteral nutrition 27 (2): 123–31. PMID 12665168.
Banerjee S, Kumar BR, Kundu TK (2004). "General transcriptional coactivator PC4 activates p53 function.". Mol. Cell. Biol. 24 (5): 2052–62. PMID 14966284.