STXBP5

From Wikipedia, the free encyclopedia

Syntaxin binding protein 5 (tomosyn)

PDB rendering based on 1urq.

Available structures: 1urq

Identifiers

Symbol(s)

STXBP5; FLJ30922; LGL3; LLGL3; MGC141942; MGC141968; Nbla04300

External IDs

OMIM: 604586 MGI: 1926058 HomoloGene: 16402

Gene ontology
Molecular Function:	• protein binding • syntaxin-1 binding
Cellular Component:	• nicotinic acetylcholine-gated receptor-channel complex • membrane • integral to membrane
Biological Process:	• exocytosis • protein transport

Orthologs

Human

Mouse

Refseq

NM_139244 (mRNA)
NP_640337 (protein)

XM_125517 (mRNA)
XP_125517 (protein)

Location

Chr 6: 147.57 - 147.75 Mb

Chr 10: 9.45 - 9.59 Mb

Pubmed search

[1]

[2]

Syntaxin binding protein 5 (tomosyn), also known as STXBP5, is a human gene.^[1]

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced variants have been identified, but their biological validity has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: STXBP5 syntaxin binding protein 5 (tomosyn).

[edit] Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Katoh M, Katoh M (2004). "Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico.". Int. J. Oncol. 24 (3): 737-42. PMID 14767561.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Widberg CH, Bryant NJ, Girotti M, et al. (2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation.". J. Biol. Chem. 278 (37): 35093-101. doi:10.1074/jbc.M304261200. PMID 12832401.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yokoyama S, Shirataki H, Sakisaka T, Takai Y (1999). "Three splicing variants of tomosyn and identification of their syntaxin-binding region.". Biochem. Biophys. Res. Commun. 256 (1): 218-22. doi:10.1006/bbrc.1999.0300. PMID 10066450.
Fujita Y, Shirataki H, Sakisaka T, et al. (1998). "Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process.". Neuron 20 (5): 905-15. PMID 9620695.