STXBP1

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Syntaxin binding protein 1
PDB rendering based on 1dn1.
Available structures: 1dn1
Identifiers
Symbol(s) STXBP1; MUNC18-1; UNC18; hUNC18; rbSec1
External IDs OMIM: 602926 MGI: 107363 HomoloGene: 2382
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6812 20910
Ensembl ENSG00000136854 ENSMUSG00000026797
Uniprot P61764 Q5WAC6
Refseq NM_001032221 (mRNA)
NP_001027392 (protein)		 NM_009295 (mRNA)
NP_033321 (protein)
Location Chr 9: 129.41 - 129.49 Mb Chr 2: 32.61 - 32.67 Mb
Pubmed search [1] [2]

Syntaxin binding protein 1, also known as STXBP1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: STXBP1 syntaxin binding protein 1.

[edit] Further reading

  • Garcia EP, McPherson PS, Chilcote TJ, et al. (1995). "rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin.". J. Cell Biol. 129 (1): 105–20. PMID 7698978. 
  • Pevsner J, Hsu SC, Scheller RH (1994). "n-Sec1: a neural-specific syntaxin-binding protein.". Proc. Natl. Acad. Sci. U.S.A. 91 (4): 1445–9. PMID 8108429. 
  • Fujita Y, Sasaki T, Fukui K, et al. (1996). "Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.". J. Biol. Chem. 271 (13): 7265–8. PMID 8631738. 
  • Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y (1996). "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants.". J. Neurosci. 16 (21): 6695–702. PMID 8824310. 
  • Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4.". J. Biol. Chem. 272 (10): 6179–86. PMID 9045631. 
  • Verhage M, de Vries KJ, Røshol H, et al. (1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion.". Neuron 18 (3): 453–61. PMID 9115738. 
  • Okamoto M, Südhof TC (1998). "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.". J. Biol. Chem. 272 (50): 31459–64. PMID 9395480. 
  • Swanson DA, Steel JM, Valle D (1998). "Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release.". Genomics 48 (3): 373–6. doi:10.1006/geno.1997.5202. PMID 9545644. 
  • Fletcher AI, Shuang R, Giovannucci DR, et al. (1999). "Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18.". J. Biol. Chem. 274 (7): 4027–35. PMID 9933594. 
  • Reed GL, Houng AK, Fitzgerald ML (1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.". Blood 93 (8): 2617–26. PMID 10194441. 
  • Dulubova I, Sugita S, Hill S, et al. (1999). "A conformational switch in syntaxin during exocytosis: role of munc18.". EMBO J. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMID 10449403. 
  • Misura KM, Scheller RH, Weis WI (2000). "Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex.". Nature 404 (6776): 355–62. doi:10.1038/35006120. PMID 10746715. 
  • Allan BB, Moyer BD, Balch WE (2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion.". Science 289 (5478): 444–8. PMID 10903204. 
  • Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMID 11927603. 
  • Ho CS, Marinescu V, Steinhilb ML, et al. (2002). "Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism.". J. Biol. Chem. 277 (30): 27021–8. doi:10.1074/jbc.M201823200. PMID 12016213. 
  • Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay.". Mol. Cell. Neurosci. 20 (2): 169–80. PMID 12093152. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Barclay JW, Craig TJ, Fisher RJ, et al. (2003). "Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.". J. Biol. Chem. 278 (12): 10538–45. doi:10.1074/jbc.M211114200. PMID 12519779. 
  • Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134. 
  • Craig TJ, Evans GJ, Morgan A (2003). "Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.". J. Neurochem. 86 (6): 1450–7. PMID 12950453. 
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