STX4

From Wikipedia, the free encyclopedia

Syntaxin 4

Identifiers

STX4; STX4A; p35-2

External IDs

OMIM: 186591 MGI: 893577 HomoloGene: 3386

Gene ontology
Molecular Function:	• protein binding • protein transporter activity
Cellular Component:	• cytoplasm • plasma membrane • integral to membrane
Biological Process:	• neurotransmitter transport • intracellular protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004604 (mRNA)
NP_004595 (protein)

NM_009294 (mRNA)
NP_033320 (protein)

Location

Chr 16: 30.95 - 30.96 Mb

Chr 7: 127.63 - 127.64 Mb

Pubmed search

[1]

[2]

Syntaxin 4, also known as STX4, is a human gene.^[1]

[edit] References

^ Entrez Gene: STX4 Syntaxin 4.

[edit] Further reading

Bennett MK, García-Arrarás JE, Elferink LA, et al. (1993). "The syntaxin family of vesicular transport receptors.". Cell 74 (5): 863–73. PMID 7690687.
Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.". Nature 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.
Li H, Hodge DR, Pei GK, Seth A (1994). "Isolation and sequence analysis of the human syntaxin-encoding gene.". Gene 143 (2): 303–4. PMID 8206394.
Jagadish MN, Fernandez CS, Hewish DR, et al. (1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.". Biochem. J. 317 ( Pt 3): 945–54. PMID 8760387.
Mandon B, Chou CL, Nielsen S, Knepper MA (1996). "Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking.". J. Clin. Invest. 98 (4): 906–13. PMID 8770861.
Timmers KI, Clark AE, Omatsu-Kanbe M, et al. (1997). "Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein.". Biochem. J. 320 ( Pt 2): 429–36. PMID 8973549.
Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4.". J. Biol. Chem. 272 (10): 6179–86. PMID 9045631.
Araki S, Tamori Y, Kawanishi M, et al. (1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c.". Biochem. Biophys. Res. Commun. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.
Inoue T, Nielsen S, Mandon B, et al. (1998). "SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles.". Am. J. Physiol. 275 (5 Pt 2): F752–60. PMID 9815132.
Reed GL, Houng AK, Fitzgerald ML (1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.". Blood 93 (8): 2617–26. PMID 10194441.
Min J, Okada S, Kanzaki M, et al. (1999). "Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes.". Mol. Cell 3 (6): 751–60. PMID 10394363.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV.". Mol. Biol. Cell 10 (7): 2285–95. PMID 10397765.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. PMID 10508479.
Paumet F, Le Mao J, Martin S, et al. (2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment.". J. Immunol. 164 (11): 5850–7. PMID 10820264.
Li L, Omata W, Kojima I, Shibata H (2001). "Direct interaction of Rab4 with syntaxin 4.". J. Biol. Chem. 276 (7): 5265–73. doi:10.1074/jbc.M003883200. PMID 11063739.
Logan MR, Lacy P, Bablitz B, Moqbel R (2002). "Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis.". J. Allergy Clin. Immunol. 109 (2): 299–306. PMID 11842301.
Dent J, Kato K, Peng XR, et al. (2002). "A prototypic platelet septin and its participation in secretion.". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 3064–9. doi:10.1073/pnas.052715199. PMID 11880646.
Perskvist N, Roberg K, Kulyté A, Stendahl O (2002). "Rab5a GTPase regulates fusion between pathogen-containing phagosomes and cytoplasmic organelles in human neutrophils.". J. Cell. Sci. 115 (Pt 6): 1321–30. PMID 11884531.
Polgár J, Chung SH, Reed GL (2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.". Blood 100 (3): 1081–3. PMID 12130530.
Scales SJ, Hesser BA, Masuda ES, Scheller RH (2002). "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.". J. Biol. Chem. 277 (31): 28271–9. doi:10.1074/jbc.M204929200. PMID 12145319.