STX2

From Wikipedia, the free encyclopedia

Syntaxin 2

Identifiers

STX2; EPIM; EPM; MGC51014; STX2A; STX2B; STX2C

External IDs

OMIM: 132350 MGI: 108059 HomoloGene: 37559

Gene ontology
Molecular Function:	• protein transporter activity
Cellular Component:	• soluble fraction • microsome • membrane • integral to membrane
Biological Process:	• intracellular protein transport • signal transduction • ectoderm development • organ morphogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001980 (mRNA)
NP_001971 (protein)

NM_007941 (mRNA)
NP_031967 (protein)

Location

Chr 12: 129.84 - 129.89 Mb

Chr 5: 129.3 - 129.32 Mb

Pubmed search

[1]

[2]

Syntaxin 2, also known as STX2, is a human gene.^[1]

The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: STX2 syntaxin 2.

[edit] Further reading

Hirai Y, Takebe K, Takashina M, et al. (1992). "Epimorphin: a mesenchymal protein essential for epithelial morphogenesis.". Cell 69 (3): 471-81. PMID 1581962.
Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic.". J. Biol. Chem. 270 (22): 13022-8. PMID 7768895.
Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.". Nature 375 (6532): 594-9. doi:10.1038/375594a0. PMID 7791877.
Hirai Y (1993). "Molecular cloning of human epimorphin: identification of isoforms and their unique properties.". Biochem. Biophys. Res. Commun. 191 (3): 1332-7. doi:10.1006/bbrc.1993.1363. PMID 8466509.
Oka Y, Hirai Y (1996). "Inductive influences of epimorphin on endothelial cells in vitro.". Exp. Cell Res. 222 (1): 189-98. doi:10.1006/excr.1996.0024. PMID 8549663.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Zha H, Remmers EF, Szpirer C, et al. (1997). "The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12.". Genomics 37 (3): 386-9. doi:10.1006/geno.1996.0574. PMID 8938452.
Betz A, Okamoto M, Benseler F, Brose N (1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.". J. Biol. Chem. 272 (4): 2520-6. PMID 8999968.
Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4.". J. Biol. Chem. 272 (10): 6179-86. PMID 9045631.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Koshida S, Hirai Y (1997). "Identification of cellular recognition sequence of epimorphin and critical role of cell/epimorphin interaction in lung branching morphogenesis.". Biochem. Biophys. Res. Commun. 234 (2): 522-5. doi:10.1006/bbrc.1997.6673. PMID 9177305.
Hirai Y, Lochter A, Galosy S, et al. (1998). "Epimorphin functions as a key morphoregulator for mammary epithelial cells.". J. Cell Biol. 140 (1): 159-69. PMID 9425164.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV.". Mol. Biol. Cell 10 (7): 2285-95. PMID 10397765.
Pabst S, Hazzard JW, Antonin W, et al. (2000). "Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions.". J. Biol. Chem. 275 (26): 19808-18. doi:10.1074/jbc.M002571200. PMID 10777504.
Kauppi M, Wohlfahrt G, Olkkonen VM (2003). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3.". J. Biol. Chem. 277 (46): 43973-9. doi:10.1074/jbc.M208315200. PMID 12198139.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Terasaki Y, Fukuda Y, Suga M, et al. (2006). "Epimorphin expression in interstitial pneumonia.". Respir. Res. 6: 6. doi:10.1186/1465-9921-6-6. PMID 15651999.
Band AM, Kuismanen E (2006). "Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments.". BMC Cell Biol. 6 (1): 26. doi:10.1186/1471-2121-6-26. PMID 15943887.
Low SH, Vasanji A, Nanduri J, et al. (2006). "Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity.". Mol. Biol. Cell 17 (2): 977-89. doi:10.1091/mbc.E05-05-0462. PMID 16339081.