STX1A

From Wikipedia, the free encyclopedia

Syntaxin 1A (brain)

PDB rendering based on 1br0.

Available structures: 1br0, 1dn1, 1ez3, 1hvv, 1jth, 1kil, 1n7s, 1sfc, 1urq

Identifiers

Symbol(s)

STX1A; HPC-1; STX1; p35-1

External IDs

OMIM: 186590 MGI: 109355 HomoloGene: 37941

Gene ontology
Molecular Function:	• SNARE binding • protein transporter activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• neurotransmitter transport • intracellular protein transport • exocytosis • regulation of insulin secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004603 (mRNA)
NP_004594 (protein)

NM_016801 (mRNA)
NP_058081 (protein)

Location

Chr 7: 72.75 - 72.77 Mb

Chr 5: 135.31 - 135.34 Mb

Pubmed search

[1]

[2]

Syntaxin 1A (brain), also known as STX1A, is a human gene.

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995).[supplied by OMIM]^[1]

[edit] See also

Syntaxin

[edit] References

^ Entrez Gene: STX1A syntaxin 1A (brain).

[edit] Further reading

Peters KW, Qi J, Johnson JP, et al. (2002). "Role of snare proteins in CFTR and ENaC trafficking.". Pflugers Arch. 443 Suppl 1: S65–9. doi:10.1007/s004240100647. PMID 11845306.
Wilson DW, Whiteheart SW, Wiedmann M, et al. (1992). "A multisubunit particle implicated in membrane fusion.". J. Cell Biol. 117 (3): 531–8. PMID 1315316.
Bennett MK, Calakos N, Scheller RH (1992). "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones.". Science 257 (5067): 255–9. PMID 1321498.
McMahon HT, Missler M, Li C, Südhof TC (1995). "Complexins: cytosolic proteins that regulate SNAP receptor function.". Cell 83 (1): 111–9. PMID 7553862.
Zhang R, Maksymowych AB, Simpson LL (1995). "Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis.". Gene 159 (2): 293–4. PMID 7622072.
Hanson PI, Otto H, Barton N, Jahn R (1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin.". J. Biol. Chem. 270 (28): 16955–61. PMID 7622514.
Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic.". J. Biol. Chem. 270 (22): 13022–8. PMID 7768895.
Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.". Nature 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.
Pevsner J, Hsu SC, Scheller RH (1994). "n-Sec1: a neural-specific syntaxin-binding protein.". Proc. Natl. Acad. Sci. U.S.A. 91 (4): 1445–9. PMID 8108429.
Betz A, Okamoto M, Benseler F, Brose N (1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.". J. Biol. Chem. 272 (4): 2520–6. PMID 8999968.
Jagadish MN, Tellam JT, Macaulay SL, et al. (1997). "Novel isoform of syntaxin 1 is expressed in mammalian cells.". Biochem. J. 321 ( Pt 1): 151–6. PMID 9003414.
Shao X, Li C, Fernandez I, et al. (1997). "Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch.". Neuron 18 (1): 133–42. PMID 9010211.
Hao JC, Salem N, Peng XR, et al. (1997). "Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes.". J. Neurosci. 17 (5): 1596–603. PMID 9030619.
Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4.". J. Biol. Chem. 272 (10): 6179–86. PMID 9045631.
Coffield JA, Bakry N, Zhang RD, et al. (1997). "In vitro characterization of botulinum toxin types A, C and D action on human tissues: combined electrophysiologic, pharmacologic and molecular biologic approaches.". J. Pharmacol. Exp. Ther. 280 (3): 1489–98. PMID 9067339.
Nakayama T, Fujiwara T, Miyazawa A, et al. (1997). "Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11.2.". Genomics 42 (1): 173–6. doi:10.1006/geno.1997.4650. PMID 9177791.
Osborne LR, Soder S, Shi XM, et al. (1997). "Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome.". Am. J. Hum. Genet. 61 (2): 449–52. PMID 9311751.
Naren AP, Nelson DJ, Xie W, et al. (1997). "Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms.". Nature 390 (6657): 302–5. doi:10.1038/36882. PMID 9384384.
Okamoto M, Südhof TC (1998). "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.". J. Biol. Chem. 272 (50): 31459–64. PMID 9395480.
Shuang R, Zhang L, Fletcher A, et al. (1998). "Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings.". J. Biol. Chem. 273 (9): 4957–66. PMID 9478941.
Vinogradova TI (January 1977). "[Destructive tuberculosis of the lung in adolescents]" (in Russian). Probl Tuberk (1): 19–22. PMID 834751.
Burgess RW, Deitcher DL, Schwarz TL (August 1997). "The synaptic protein syntaxin1 is required for cellularization of Drosophila embryos". J. Cell Biol. 138 (4): 861–75. PMID 9265652.
Littleton JT, Chapman ER, Kreber R, Garment MB, Carlson SD, Ganetzky B (August 1998). "Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly". Neuron 21 (2): 401–13. PMID 9728921.
Lagow RD, Bao H, Cohen EN, et al (April 2007). "Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion". PLoS Biol. 5 (4): e72. doi:10.1371/journal.pbio.0050072. PMID 17341138.