Talk:Streptomycin

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The story of the discovery of streptomycin, and in particular the question of who should have received the credit, seems quite controversial. This would probably require some editing to explain the situation better; in the meantime, the Revision as of 09:36, 3 September 2005 by User:The Phoenix seems more neutral than the subsequent revision by User:Gwax. I suggest to revert this edit until a better formulation is found. Schutz 21:37, 29 September 2005 (UTC)

Contents 1 Streptomycin - used in treatment for Pneumonic plague 2 NPOV 3 wrong chemical structure 4 Simple English Possible? 5 First line for TB 6 Incorrect citation

[edit] Streptomycin - used in treatment for Pneumonic plague

Secondary pneumonic plague can be simplistically considered as an evolved form of bubonic plague where bacterial infection spreads to the lungs resulting in symptoms consistent with those of TB. It should be noted that the symptoms of secondary pneumonic plague are of rapid onset (2-3 days) and much higher severity than those seen in tuberculosis infection. Untreated pneumonic plague is almost uniformly fatal.

Stremptomycin has been shown to be somewhat effective in treatment - usually following use of other antibiotics such as tetracycline where treatment has been unsuccessful - possibly due to treatment being applied too late in the disease cycle.

More advanced treatments may now exist - do not use the above as medical advice - seek professional medical advice.

[edit] NPOV

As has already been seen, I am not neutral on the matter of this article so I won't try editing it myself but in its current state it exibits a strong bias (almost slander) against Selman Waksman and as such I have placed the NPOV tag on the page. Both the Albert Schatz and Selman Waksman pages present a more neutral appraoch to the issue. --Gwax 21:04, 22 December 2005 (UTC)

After researching this interesting story on the discovery of streptomycin for a class that I teach, I agree that the current listing on Wikipedia for streptomycin exhibits a strong bias against Selman Waksman (and as stated above, bordering on slander). The story of Selman Waksman on the Wikipedia site shows a much more balanced view of the controvery. UMIMPMI 14:51, 7 February 2006 (UTC)

I have now edited this page to present a neutral and more comprehensive discussion of this topic UMIMPMI 15:30, 7 February 2006 (UTC)

It looks good to me; I think the tag can be removed. Schutz 15:34, 7 February 2006 (UTC)

[edit] wrong chemical structure

the submitted image of the chemical structure is incorrect,the IUPAC name for streptomycin is : 5-(2,4-diguanidino-3,5,6-trihydroxy-cyclohexoxy)-4- [4,5-dihydroxy-6-(hydroxymethyl) -3-methylamino-tetrahydropyran-2-yl] oxy-3-hydroxy-2-methyl-tetrahydrofuran-3-carbaldehyde

the bold states a methyl group at the 2-position in the furan ( 5 membered one in the middle) and the image contains a hydroxyl group

The unsigned contributor above is correct. For example, see the chemical structure at http://www.bmb.leeds.ac.uk/mbiology/ug/ugteach/icu8/antibiotics/antimycobacterials.html susato 16:06, 19 October 2007 (UTC)

[edit] Simple English Possible?

Would it be possible to make a simple english version of this... please? 72.75.102.121 16:49, 18 March 2007 (UTC)

[edit] First line for TB

Although streptomycin is not commonly used as first-line treatment for TB, this is not because it is not a first line drug! Indeed, it IS on the WHO list of first line drugs for TB. It is because streptomycin has to be given by daily intramuscular injection, which is painful and one of the major side-effects of streptomycin is permanent sensorineural deafness. If there are no objections, I will amend the article to reflect this. --Gak 02:55, 18 May 2007 (UTC)

[edit] Incorrect citation

This article claims that E. coli can be resistant to streptomycin if they have an aadA gene activated, and then cites a Joung 2000 article, found at http://www.pnas.org/cgi/content/full/97/13/7382 This article makes absolutely no mention of streptomycin, but rather of resistance to spectinomycin. Spectinomycin is produced by a bacterium from the same genus as streptomycin, but not the same species. Even though spectinomycin behaves similarly to streptomycin, they have different chemical structures and I think it's an unethical extrapolation to assume that activation of the aadA gene will also create resistance to streptomycin. —Preceding unsigned comment added by 143.44.70.225 (talk) 04:55, 9 May 2008 (UTC)