STK19

From Wikipedia, the free encyclopedia

Serine/threonine kinase 19

Identifiers

STK19; RP1; D6S60; D6S60E; G11; HLA-RP1; MGC117388

External IDs

OMIM: 604977 MGI: 1860085 HomoloGene: 10449

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • kinase activity • transferase activity • manganese ion binding
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004197 (mRNA)
NP_004188 (protein)

NM_019442 (mRNA)
NP_062315 (protein)

Location

Chr 6: 32.05 - 32.09 Mb

Chr 17: 34.43 - 34.44 Mb

Pubmed search

[1]

[2]

Serine/threonine kinase 19, also known as STK19, is a human gene.^[1]

This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: STK19 serine/threonine kinase 19.

[edit] Further reading

Yu CY (1991). "The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene.". J. Immunol. 146 (3): 1057-66. PMID 1988494.
Sargent CA, Anderson MJ, Hsieh SL, et al. (1994). "Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex.". Hum. Mol. Genet. 3 (3): 481-8. PMID 8012361.
Shen L, Wu LC, Sanlioglu S, et al. (1994). "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.". J. Biol. Chem. 269 (11): 8466-76. PMID 8132574.
Ulgiati D, Townend DC, Christiansen FT, et al. (1996). "Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype.". Immunogenetics 43 (4): 250-2. PMID 8575831.
Yang Z, Shen L, Dangel AW, et al. (1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA.". Genomics 53 (3): 338-47. doi:10.1006/geno.1998.5499. PMID 9799600.
Gomez-Escobar N, Chou CF, Lin WW, et al. (1998). "The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase.". J. Biol. Chem. 273 (47): 30954-60. PMID 9812991.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621-36. doi:10.1101/gr.1736803. PMID 14656967.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Wadle A, Mischo A, Henrich PP, et al. (2005). "Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity.". Int. J. Cancer 117 (6): 896-904. doi:10.1002/ijc.21259. PMID 15986447.