STK10

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Serine/threonine kinase 10
PDB rendering based on 2j7t.
Available structures: 2j7t
Identifiers
Symbol(s) STK10; LOK; PRO2729
External IDs OMIM: 603919 MGI: 1099439 HomoloGene: 38122
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6793 20868
Ensembl ENSG00000072786 ENSMUSG00000020272
Uniprot O94804 Q5SS74
Refseq XM_001129121 (mRNA)
XP_001129121 (protein)		 NM_009288 (mRNA)
NP_033314 (protein)
Location Chr 5: 171.4 - 171.55 Mb Chr 11: 32.43 - 32.52 Mb
Pubmed search [1] [2]

Serine/threonine kinase 10, also known as STK10, is a human gene.[1]

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.[1]

[edit] References

  1. ^ a b Entrez Gene: STK10 serine/threonine kinase 10.

[edit] Further reading

  • Kuramochi S, Moriguchi T, Kuida K, et al. (1997). "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes.". J. Biol. Chem. 272 (36): 22679-84. PMID 9278426. 
  • Kuramochi S, Matsuda Y, Okamoto M, et al. (1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues.". Immunogenetics 49 (5): 369-75. PMID 10199912. 
  • Tao L, Wadsworth S, Mercer J, et al. (2002). "Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.". Biochem. J. 363 (Pt 1): 175-82. PMID 11903060. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Walter SA, Cutler RE, Martinez R, et al. (2003). "Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.". J. Biol. Chem. 278 (20): 18221-8. doi:10.1074/jbc.M212556200. PMID 12639966. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Bignell G, Smith R, Hunter C, et al. (2006). "Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.". Genes Chromosomes Cancer 45 (1): 42-6. doi:10.1002/gcc.20265. PMID 16175573. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243. 
  • Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537-47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. 
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