STIM1

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Stromal interaction molecule 1
Identifiers
Symbol(s)	STIM1; D11S4896E; GOK
External IDs	OMIM: 605921 MGI: 107476 HomoloGene: 20681
Gene ontology Molecular Function: • calcium ion binding • protein binding Cellular Component: • endoplasmic reticulum • integral to plasma membrane • membrane • integral to endoplasmic reticulum membrane Biological Process: • detection of calcium ion • ion transport • activation of store-operated calcium channel activity • regulation of calcium ion transport
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	6786	20866
Ensembl	ENSG00000167323	ENSMUSG00000030987
Uniprot	Q13586	Q3TUX9
Refseq	NM_003156 (mRNA) NP_003147 (protein)	XM_980199 (mRNA) XP_985293 (protein)
Location	Chr 11: 3.83 - 4.07 Mb	Chr 7: 102.14 - 102.31 Mb
Pubmed search	[1]	[2]

Stromal interaction molecule 1, also known as STIM1, is a human gene.

This gene encodes a type 1 transmembrane protein of unknown function. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.^[1]

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