Sterol esterase

From Wikipedia, the free encyclopedia

In enzymology, a sterol esterase (EC 3.1.1.13) is an enzyme that catalyzes the chemical reaction

a steryl ester + H₂O $\rightleftharpoons$ a sterol + a fatty acid

Thus, the two substrates of this enzyme are steryl ester and H₂O, whereas its two products are sterol and fatty acid.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is steryl-ester acylhydrolase. Other names in common use include cholesterol esterase, cholesteryl ester synthase, triterpenol esterase, cholesteryl esterase, cholesteryl ester hydrolase, sterol ester hydrolase, cholesterol ester hydrolase, cholesterase, and acylcholesterol lipase. This enzyme participates in bile acid biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1AQL and 2BCE.

[edit] References

IUBMB entry for 3.1.1.13
BRENDA references for 3.1.1.13 (Recommended.)
PubMed references for 3.1.1.13
PubMed Central references for 3.1.1.13
Google Scholar references for 3.1.1.13
Hyun J, Kothari H, Herm E, Mortenson J, Treadwell CR, Vahouny GV (1969). "Purification and properties of pancreatic juice cholesterol esterase". J. Biol. Chem. 244: 1937–45. PMID 5780846.
Okawa Y, Yamaguchi T (Tokyo). "Studies on sterol-ester hydrolase from Fusarium oxysporum. I Partial purification and properties". J. Biochem.: 1209–15. PMID 19426.
Vahouny GV, Treadwell CR (1968). "Enzymatic synthesis and hydrolysis of cholesterol esters". Methods. Biochem. Anal. 16: 219–72. doi:10.1002/9780470110348.ch4. PMID 4877146.
Warnaar F (1987). "Triterpene ester synthesis in latex of Euphorbia species". Phytochemistry 26: 2715–2721. doi:10.1016/S0031-9422(00)83578-5.