Sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

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In enzymology, a sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) is an enzyme that catalyzes the chemical reaction

3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ $\rightleftharpoons$ 4alpha-methyl-5alpha-cholest-7-en-3-one + CO₂ + NAD(P)H

The 3 substrates of this enzyme are 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate, NAD⁺, and NADP⁺, whereas its 4 products are 4alpha-methyl-5alpha-cholest-7-en-3-one, CO₂, NADH, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:N AD(P)+ 3-oxidoreductase (decarboxylating). Other names in common use include 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase, (decarboxylating), 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, and sterol 4alpha-carboxylic decarboxylase. This enzyme participates in biosynthesis of steroids.

[edit] References

IUBMB entry for 1.1.1.170
BRENDA references for 1.1.1.170 (Recommended.)
PubMed references for 1.1.1.170
PubMed Central references for 1.1.1.170
Google Scholar references for 1.1.1.170
Brady DR, Crowder RD, Hayes WJ (1980). "Mixed function oxidases in sterol metabolism. Source of reducing equivalents". J. Biol. Chem. 255: 10624–9. PMID 7430141.
Rahimtula AD, Gaylor JL (1972). "Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase". J. Biol. Chem. 247: 9–15. PMID 4401584.