Sterigmatocystin 8-O-methyltransferase

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In enzymology, a sterigmatocystin 8-O-methyltransferase (EC 2.1.1.110) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + sterigmatocystin $\rightleftharpoons$ S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin

Thus, the two substrates of this enzyme are S-adenosyl methionine and sterigmatocystin, whereas its two products are S-adenosylhomocysteine and 8-O-methylsterigmatocystin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase. Other names in common use include sterigmatocystin methyltransferase, O-methyltransferase II, sterigmatocystin 7-O-methyltransferase (incorrect), S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase, and (incorrect).

[edit] References

IUBMB entry for 2.1.1.110
BRENDA references for 2.1.1.110 (Recommended.)
PubMed references for 2.1.1.110
PubMed Central references for 2.1.1.110
Google Scholar references for 2.1.1.110
Bhatnagar D, McCormick SP, Lee LS, Hill RA (1987). "Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus". Appl. Environ. Microbiol. 53: 1028–33. PMID 3111363.
Yabe K, Ando Y, Hashimoto J, Hamasaki T (1989). "Two distinct O-methyltransferases in aflatoxin biosynthesis". Appl. Environ. Microbiol. 55: 2172–7. PMID 2802602.