STEAP1

From Wikipedia, the free encyclopedia

Six transmembrane epithelial antigen of the prostate 1

Identifiers

STEAP1; MGC19484; PRSS24; STEAP

External IDs

OMIM: 604415 MGI: 1917608 HomoloGene: 8256

Gene ontology
Molecular Function:	• iron ion binding • channel activity • oxidoreductase activity • FAD binding
Cellular Component:	• plasma membrane • integral to plasma membrane • intercellular junction
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001131341 (mRNA)
XP_001131341 (protein)

NM_027399 (mRNA)
NP_081675 (protein)

Location

Chr 7: 89.62 - 89.63 Mb

Chr 5: 5.74 - 5.76 Mb

Pubmed search

[1]

[2]

Six transmembrane epithelial antigen of the prostate 1, also known as STEAP1, is a human gene.^[1]

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.^[1]

[edit] References

^ ^a ^b Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1.

[edit] Further reading

"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Hubert RS, Vivanco I, Chen E, et al. (2000). "STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors.". Proc. Natl. Acad. Sci. U.S.A. 96 (25): 14523–8. PMID 10588738.
Yang D, Holt GE, Velders MP, et al. (2001). "Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice.". Cancer Res. 61 (15): 5857–60. PMID 11479226.
Korkmaz KS, Elbi C, Korkmaz CG, et al. (2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer.". J. Biol. Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rodeberg DA, Nuss RA, Elsawa SF, Celis E (2005). "Recognition of six-transmembrane epithelial antigen of the prostate-expressing tumor cells by peptide antigen-induced cytotoxic T lymphocytes.". Clin. Cancer Res. 11 (12): 4545–52. doi:10.1158/1078-0432.CCR-04-2235. PMID 15958640.