STC1

From Wikipedia, the free encyclopedia

Stanniocalcin 1

Identifiers

External IDs

OMIM: 601185 MGI: 109131 HomoloGene: 2374

Gene ontology
Molecular Function:	• hormone activity
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• cellular calcium ion homeostasis • cell surface receptor linked signal transduction • cell-cell signaling • response to nutrient

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003155 (mRNA)
NP_003146 (protein)

NM_009285 (mRNA)
NP_033311 (protein)

Location

Chr 8: 23.76 - 23.77 Mb

Chr 14: 67.98 - 67.99 Mb

Pubmed search

[1]

[2]

Stanniocalcin 1, also known as STC1, is a human gene.^[1]

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.^[1]

[edit] References

^ ^a ^b Entrez Gene: STC1 stanniocalcin 1.

[edit] Further reading

Chang AC, Jellinek DA, Reddel RR (2004). "Mammalian stanniocalcins and cancer.". Endocr. Relat. Cancer 10 (3): 359-73. PMID 14503913.
Liang P, Averboukh L, Keyomarsi K, et al. (1993). "Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells.". Cancer Res. 52 (24): 6966-8. PMID 1458489.
Chang AC, Janosi J, Hulsbeek M, et al. (1996). "A novel human cDNA highly homologous to the fish hormone stanniocalcin.". Mol. Cell. Endocrinol. 112 (2): 241-7. PMID 7489828.
Wagner GF, Guiraudon CC, Milliken C, Copp DH (1995). "Immunological and biological evidence for a stanniocalcin-like hormone in human kidney.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 1871-5. PMID 7892193.
Olsen HS, Cepeda MA, Zhang QQ, et al. (1996). "Human stanniocalcin: a possible hormonal regulator of mineral metabolism.". Proc. Natl. Acad. Sci. U.S.A. 93 (5): 1792-6. PMID 8700837.
Chang AC, Jeffrey KJ, Tokutake Y, et al. (1998). "Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats.". Genomics 47 (3): 393-8. doi:10.1006/geno.1997.5120. PMID 9480753.
Zhang KZ, Westberg JA, Paetau A, et al. (1998). "High expression of stanniocalcin in differentiated brain neurons.". Am. J. Pathol. 153 (2): 439-45. PMID 9708804.
Varghese R, Wong CK, Deol H, et al. (1998). "Comparative analysis of mammalian stanniocalcin genes.". Endocrinology 139 (11): 4714-25. PMID 9794484.
Zhang K, Lindsberg PJ, Tatlisumak T, et al. (2000). "Stanniocalcin: A molecular guard of neurons during cerebral ischemia.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3637-42. doi:10.1073/pnas.070045897. PMID 10725397.
Jellinek DA, Chang AC, Larsen MR, et al. (2001). "Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells.". Biochem. J. 350 Pt 2: 453-61. PMID 10947959.
Varghese R, Gagliardi AD, Bialek PE, et al. (2002). "Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice.". Endocrinology 143 (3): 868-76. PMID 11861508.
McCudden CR, James KA, Hasilo C, Wagner GF (2003). "Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism.". J. Biol. Chem. 277 (47): 45249-58. doi:10.1074/jbc.M205954200. PMID 12223480.
Serlachius M, Alitalo R, Olsen HS, Andersson LC (2002). "Expression of stanniocalcin-1 in megakaryocytes and platelets.". Br. J. Haematol. 119 (2): 359-63. PMID 12406069.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sheikh-Hamad D, Bick R, Wu GY, et al. (2003). "Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure.". Am. J. Physiol. Heart Circ. Physiol. 285 (1): H442-8. doi:10.1152/ajpheart.01071.2002. PMID 12663264.
Zlot C, Ingle G, Hongo J, et al. (2004). "Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor.". J. Biol. Chem. 278 (48): 47654-9. doi:10.1074/jbc.M301353200. PMID 14500721.
McCudden CR, Majewski A, Chakrabarti S, Wagner GF (2004). "Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas.". Mol. Cell. Endocrinol. 213 (2): 167-72. doi:10.1016/j.mce.2003.10.042. PMID 15062564.
Luo CW, Kawamura K, Klein C, Hsueh AJ (2005). "Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors.". Mol. Endocrinol. 18 (8): 2085-96. doi:10.1210/me.2004-0066. PMID 15131261.
Serlachius M, Andersson LC (2004). "Upregulated expression of stanniocalcin-1 during adipogenesis.". Exp. Cell Res. 296 (2): 256-64. doi:10.1016/j.yexcr.2004.02.016. PMID 15149855.