STAT5B

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Signal transducer and activator of transcription 5B
PDB rendering based on 1y1u.
Available structures: 1y1u
Identifiers
Symbol(s)	STAT5B; STAT5
External IDs	OMIM: 604260 MGI: 103035 HomoloGene: 55718
Gene ontology Molecular Function: • transcription factor activity • signal transducer activity • calcium ion binding Cellular Component: • nucleus • cytoplasm Biological Process: • luteinization • natural killer cell differentiation • transcription • intracellular signaling cascade • JAK-STAT cascade • female pregnancy • lactation • positive regulation of cell proliferation • regulation of steroid metabolic process • cytokine and chemokine mediated signaling pathway • sequestering of lipid • regulation of cell adhesion • regulation of epithelial cell differentiation • positive regulation of body size • positive regulation of activated T cell proliferation • progesterone metabolic process • T cell homeostasis • negative regulation of apoptosis • positive regulation of interleukin-2 biosynthetic process • positive regulation of B cell differentiation • negative regulation of erythrocyte differentiation • positive regulation of survival gene product activity • positive regulation of progression through mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • development of secondary female sexual characteristics • development of secondary male sexual characteristics • positive regulation of inflammatory response
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	6777	20851
Ensembl	ENSG00000173757	ENSMUSG00000020919
Uniprot	P51692	Q9R0X8
Refseq	NM_012448 (mRNA) NP_036580 (protein)	NM_011489 (mRNA) NP_035619 (protein)
Location	Chr 17: 37.6 - 37.68 Mb	Chr 11: 100.6 - 100.67 Mb
Pubmed search	[1]	[2]

Signal transducer and activator of transcription 5B, also known as STAT5B, is a human gene.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.^[1]

[edit] See also

• STAT5

[edit] References

[edit] Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.