ST5 (gene)

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Suppression of tumorigenicity 5
Identifiers
Symbol(s) ST5; DENND2B; HTS1; MGC33090; p126
External IDs OMIM: 140750 MGI: 108517 HomoloGene: 3951
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6764 76954
Ensembl ENSG00000166444 ENSMUSG00000031024
Uniprot P78524 Q05BD9
Refseq NM_005418 (mRNA)
NP_005409 (protein)		 NM_001001326 (mRNA)
NP_001001326 (protein)
Location Chr 11: 8.67 - 8.82 Mb Chr 7: 109.32 - 109.41 Mb
Pubmed search [1] [2]

Suppression of tumorigenicity 5, also known as ST5, is a human gene.[1]

This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.[1]

[edit] References

  1. ^ a b Entrez Gene: ST5 suppression of tumorigenicity 5.

[edit] Further reading

  • Lichy JH, Modi WS, Seuanez HN, Howley PM (1992). "Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells.". Cell Growth Differ. 3 (8): 541–8. PMID 1390339. 
  • Lichy JH, Majidi M, Elbaum J, Tsai MM (1997). "Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression.". Nucleic Acids Res. 24 (23): 4700–8. PMID 8972856. 
  • Majidi M, Hubbs AE, Lichy JH (1998). "Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5.". J. Biol. Chem. 273 (26): 16608–14. PMID 9632734. 
  • Hubbs AE, Majidi M, Lichy JH (1999). "Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology.". Oncogene 18 (15): 2519–25. doi:10.1038/sj.onc.1202554. PMID 10229203. 
  • Majidi M, Gutkind JS, Lichy JH (2000). "Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells.". J. Biol. Chem. 275 (9): 6560–5. PMID 10692462. 
  • Amid C, Bahr A, Mujica A, et al. (2001). "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7.". Cytogenet. Cell Genet. 93 (3-4): 284–90. PMID 11528127. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
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